Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Cellulose is a well-recognized insoluble dietary fiber commonly used to manage and prevent constipation in adults. The scientific basis for its use lies in its physicochemical properties: cellulose is not digested by human enzymes and passes through the gastrointestinal tract largely intact. This increases stool bulk and water content, which stimulates peristalsis and promotes more regular bowel movements. Numerous clinical guidelines, including those from the American Gastroenterological Association and the National Institute for Health and Care Excellence (NICE), recommend increasing dietary fiber intake—including cellulose—for individuals suffering from constipation. Several randomized controlled trials and meta-analyses have demonstrated that supplementation with insoluble fibers such as cellulose improves stool frequency and consistency in adults with chronic constipation. Cellulose is found naturally in many plant-based foods (such as vegetables, fruits, and whole grains), and it is also available as a purified supplement (sometimes labeled as microcrystalline cellulose). While soluble fibers (like psyllium) may have additional benefits for some patients, insoluble fibers such as cellulose remain a cornerstone of dietary management for constipation. The evidence supporting cellulose’s efficacy is robust, though individual responses can vary, and some people may experience bloating or discomfort at high intakes. Overall, cellulose is considered a safe and effective first-line option for the dietary treatment of constipation in adults.

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