Methyl Combo
60 capsulesStock #: 21689
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Availability: In stock as of 05/11/2026
Expiration Date: 04/2027
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Technical information
Ingredient list
| Ingredient | Amount |
| Folate | 1,333 mcg DFE |
| Vitamin B12 sourced from methylcobalamin | 1,000 mcg |
Recommended Use
Take 1 vegcap twice daily, or as directed by your healthcare practitioner.
Serving size: 1
Days Supply: 30
Cost Per Day: $1.05
Product Categories: Energy, Immune System, Nervous System, Pregnancy, Vitamins / Minerals
UPC: 099904216891
Product Information
Why take this product?
- Contributes to the maintenance of normal neurological and psychological functions*
- Contributes to a reduction in tiredness and fatigue
- Supports the nervous and immune systems
- Provides nutrients essential for prenatal development
- Veggie Capsule
- Supports general well-being
How it works
In its natural form, folic acid has to pass through four enzymatic conversions before becoming the biologically active form of methyl folate known as methyltetrahydrofolate. Similarly, vitamin B12 has to pass through three enzymatic conversions before becoming the active form methylcobalamin. A 2008 study by the World Health Organization concluded that, “…deficiencies of [Folate and Vitamin B12] may be a public health problem that could affect many millions of people throughout the world.” Methyl Combo bypasses these conversion processes and delivers the active forms of B12 and Folic Acid, methylcobalamin and methylfolate. When these two influential vitamins are in their bioavailable state, they pair up and contribute to the methionine synthesis cycle. This cycle takes the Methyl Combo vitamins and creates methionine, an essential amino acid. Methionine is required for the healthy function of cells, proteins, enzymes, neurotransmitters, metabolic function, etc.
Frequently Asked Questions
Methyl Combo is Nature's Sunshine's formula that delivers the already-active forms of two essential B vitamins — methylfolate (active folic acid) and methylcobalamin (active vitamin B12). By providing these pre-converted forms, Methyl Combo bypasses the multiple enzymatic steps your body would normally need to make these vitamins usable.
In their natural forms, folic acid and vitamin B12 each require several enzymatic conversions before your body can actually use them. Some people have difficulty completing those conversions efficiently. Methyl Combo provides the bioavailable forms so your body can put them to work right away, supporting the methionine synthesis cycle, which is important for healthy cell function, neurotransmitter production, and overall metabolic function.
Methyl Combo may be a great fit for anyone looking to support their energy levels, nervous system, or immune health with active B vitamins. It's also categorized under pregnancy support, as folate is well known for its importance during that time. Anyone who suspects they may not efficiently convert standard B vitamins could find this formula especially helpful.
Each bottle contains 60 capsules. We recommend following the dosage instructions on the label, typically taken with a meal for best absorption. If you're pregnant, nursing, or have specific health concerns, it's always a good idea to check with your healthcare provider before starting any new supplement.
While Nature's Sunshine offers other B vitamin formulas that provide a broader B-complex, Methyl Combo is specifically designed to deliver the methylated, bioavailable forms of B12 and folate. This targeted approach makes it a standout choice for those who want to ensure they're getting these two critical vitamins in their most readily usable state, without relying on the body's conversion process.
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