Mullein (Verbascum thapsus) has a longstanding tradition in Western herbal medicine as a remedy for respiratory ailments, including pertussis (whooping cough). Historical records and 19th-century herbal texts frequently reference mullein as a soothing agent for dry, irritating coughs, bronchitis, and pertussis. The leaves and flowers were typically prepared as teas, syrups, or tinctures, valued for their supposed ability to loosen mucus and calm inflamed airways.

The rationale for its use in pertussis stems from its demulcent (soothing to mucous membranes) and mild expectorant properties, attributed to constituents such as mucilage, saponins, and flavonoids. These substances may help ease the paroxysmal coughing characteristic of pertussis by coating the throat and promoting mucus expulsion.

However, scientific validation for mullein’s effectiveness specifically against pertussis is limited. While some laboratory studies have demonstrated antibacterial and anti-inflammatory activities of mullein extracts, no clinical trials or robust scientific evidence directly support its benefit in treating whooping cough. Consequently, modern use is largely based on tradition and anecdotal reports rather than rigorous research.

In summary, mullein’s application in pertussis care is justified by historical use and theoretical mechanisms rather than established scientific proof. It should not be considered a substitute for medical treatment, especially given the seriousness of pertussis in children and vulnerable individuals.