Evidence supporting the use of: Turmeric
For the health condition: Diabetic Retinopathy

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Turmeric, specifically its active compound curcumin, has been the subject of scientific investigation for its potential role in supporting the treatment of diabetic retinopathy (DR). Diabetic retinopathy is a complication of diabetes characterized by damage to the retinal blood vessels, primarily due to chronic hyperglycemia-induced oxidative stress and inflammation. Curcumin is known for its anti-inflammatory, antioxidant, and anti-angiogenic properties, which are relevant to the pathological mechanisms underlying DR. Preclinical studies in animal models have demonstrated that curcumin supplementation can reduce retinal oxidative stress, inhibit the formation of abnormal blood vessels (neovascularization), and attenuate inflammatory responses in the retina. These effects are largely attributed to curcumin’s ability to modulate pathways such as NF-κB signaling and to decrease levels of pro-inflammatory cytokines and vascular endothelial growth factor (VEGF). However, clinical evidence in humans remains limited and largely preliminary. A few small pilot studies and clinical trials have suggested potential benefits, but issues such as poor bioavailability of curcumin pose challenges for its translation into clinical practice. As a result, while there is a scientific rationale and preclinical evidence supporting the use of turmeric/curcumin in diabetic retinopathy, robust human data are lacking, and it is not yet a standard therapy. Ongoing research, including trials using enhanced-bioavailability formulations, may clarify its clinical utility in the future.

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Other health conditions supported by turmeric

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