Pycnogenol

Condiciones de salud que Pycnogenol puede ayudar a apoyar.

• Abuso y TraumaCientífico

  Pycnogenol (French maritime pine bark extract, standardized procyanidins and catechins) was evaluated in a randomized, double-blind, placebo-controlled exploratory trial for allergic rhinitis in birch-pollen-allergic subjects. In the second year (39 subjects, treatment 5–8 weeks before pollen season), Pycnogenol showed 35% lower eye symptom scores and 20.5% lower nasal symptom scores versus placebo, and the increase in birch-specific IgE post-season was substantially lower in the Pycnogenol group. Several clinical trials also suggest relief of allergic asthma symptoms.

• Infección de oído o dolor de oídoCientífico

  Pycnogenol (French maritime pine bark extract) improves endothelial function in stable coronary artery disease. A 2012 double-blind, randomized, placebo-controlled crossover RCT published in the European Heart Journal found Pycnogenol improved endothelial function in stable CAD patients by reducing oxidative stress. Authoritative evidence databases list Pycnogenol among natural treatments associated with angina.

• HipocondríaCientífico

  Pycnogenol (French maritime pine bark extract) has demonstrated antioxidant defense activity through multiple verified mechanisms, supported by both preclinical and human clinical evidence. It directly scavenges reactive oxygen and nitrogen species, upregulates endogenous antioxidants (SOD, glutathione), and regenerates vitamins C and E. Human trials have measured significant reductions in oxidative stress biomarkers such as F2-isoprostanes and malondialdehyde. Evidence quality is promising but further large, well-powered RCTs are needed to standardize dosing and indication-specific outcomes.

• Síndrome de Inmunodeficiencia AdquiridaCientífico

  Pycnogenol (French maritime pine bark extract) is a standardized OPC-rich extract with multiple clinical trials demonstrating improved endothelial function, reduced blood pressure, and decreased arterial oxidative stress. A 2012 meta-analysis (Phytotherapy Research) found Pycnogenol associated with significant reductions in systolic and diastolic BP. It enhances NO production via eNOS stimulation and protects vascular endothelium from oxidative damage.

• EccemaCientífico

  Pycnogenol (French maritime pine bark extract, Pinus pinaster) is a standardized polyphenol mixture containing procyanidins and phenolic acids. Multiple RCTs demonstrate improvements in knee OA pain and function; a 2017 dietary supplement meta-analysis (69 RCTs) found pycnogenol had a large effect size (>0.80) for short-term OA pain reduction. The Arthritis Foundation lists it as having limited but supportive evidence for knee OA.

• EdemaCientífico

  Pycnogenol is a proprietary pine bark extract standardized for oligomeric proanthocyanidins. A double-blind RCT in 60 children with mild-to-moderate asthma found significant improvement in lung function and symptom scores with Pycnogenol vs. placebo over 3 months. Adult trials also showed adjunct benefit to inhaled corticosteroid therapy.

• HipotensiónCientífico

  Pycnogenol, a standardized extract from French maritime pine bark rich in procyanidins, has been assessed in multiple RCTs and several meta-analyses for blood pressure effects. A 2018 meta-analysis of 9 trials found beneficial effects on BP. Mechanisms include ACE inhibition and NO-mediated vasodilation.

• AneurismaCientífico

  Pycnogenol (French maritime pine bark extract) is a standardized extract containing proanthocyanidins with anti-inflammatory, antioxidant, and chondroprotective activities. Two randomized clinical trials found Pycnogenol supplementation significantly reduced OA pain, stiffness, and requirement for NSAIDs versus placebo. A 2008 RCT demonstrated Pycnogenol reduced serum inflammatory biomarkers and improved WOMAC scores in 100 knee OA patients.

• Válvula IleocecalCientífico

  Pycnogenol (French maritime pine bark extract, rich in OPCs) has been shown in RCTs to modestly reduce total cholesterol and LDL-C while improving endothelial function. Its primary relevant mechanism is reduction of LDL oxidation and anti-inflammatory effects on the arterial wall.

• Apetito (excesivo)Científico

  Pycnogenol (French maritime pine bark extract) has over 35 years of research confirming its ability to improve blood flow, strengthen venous walls, and reduce symptoms of chronic venous insufficiency. A prospective controlled study of 86 patients with severe CVI demonstrated Pycnogenol (150–300 mg/day) outperformed diosmin-hesperidin (Daflon) in reducing oedema, skin flux, and capillary filtration while improving tissue oxygenation. It upregulates endothelial nitric oxide synthase, promoting vasodilation.

• Ira (excesiva)Científico

  Pycnogenol (standardized French maritime pine bark extract) is a well-studied source of oligomeric proanthocyanidins that inhibit collagen-degrading enzymes, elevate intracellular vitamin C, and reduce connective tissue inflammation. RCTs show significant improvement in OA pain/function and skin connective tissue elasticity. It is among the most evidence-supported botanical extracts for connective tissue protection.

• Ayudas Atléticas y para el EjercicioCientífico

  Pycnogenol (French maritime pine bark extract) is a standardized oligomeric proanthocyanidin complex with documented antioxidant, anti-inflammatory, and tyrosinase-inhibiting properties. It is specifically listed among naturally derived topical depigmenting agents with significant benefits in managing periorbital hyperpigmentation in a 2025 PMC-indexed clinical analysis (PMC12235579).

• DesmayoCientífico

  Pycnogenol, a standardized extract from French maritime pine bark (Pinus pinaster), was tested in a controlled study of 58 surgically confirmed endometriosis patients. Oral administration of 60 mg/day for 48 weeks progressively reduced pain scores and CA-125 levels; unlike GnRH-agonist comparator, no hormonal suppression occurred and five patients became pregnant.

• FiebreCientífico

  Pycnogenol (French maritime pine bark extract) is rich in procyanidins and phenolic acids. A pilot clinical trial in women found Pycnogenol supplementation over 6 months significantly increased hair density and hair growth scores. Its mechanisms include improved scalp microcirculation, antioxidant activity, and promotion of dermal papilla cell proliferation.

• BronquitisCientífico

  Pycnogenol is a standardized French maritime pine bark extract rich in oligomeric proanthocyanidins with multiple clinical trials demonstrating anti-aging effects including improved skin elasticity and hydration, reduced vascular aging, better cognitive function in older adults, and reduced inflammaging markers.

• Cáncer (prevención)Científico

  Pycnogenol (French maritime pine bark extract) has been studied in multiple RCTs for menopausal symptoms including hot flashes. A double-blind RCT in 200 peri-menopausal women and a second trial in 38 women both demonstrated significant reductions in hot flash severity. Mechanism is non-hormonal, involving vascular relaxation via nitric oxide pathways.

• Colesterol (alto)Científico

  A multicenter, randomized, double-blind, placebo-controlled trial showed Pycnogenol (French maritime pine bark extract) significantly lowered menstrual pain and reduced analgesic medication use in dysmenorrhea. An open clinical trial also confirmed significant pain score reduction. Pycnogenol inhibits inflammation and reduces prostaglandin-driven uterine cramping.

• Cólico (adultos)Científico

  Pycnogenol (French maritime pine bark extract) is a standardized polyphenolic extract that improves microcirculation and reduces oxidative stress and neuroinflammation relevant to peripheral nerve blood supply. It is listed in authoritative peripheral neuropathy evidence databases alongside methylcobalamin, ALC, and ALA. Clinical studies in diabetic microvascular complications show it significantly improves microvascular function and neuropathic symptoms.

• Colon (espástico)Científico

  Pycnogenol (French maritime pine bark extract) stimulates eNOS transcription and activity and scavenges superoxide that degrades NO, enhancing endothelial NO bioavailability. Human clinical studies show improved vascular function and blood pressure, and its combination with L-arginine has documented NO-mediated improvements in erectile dysfunction.

• Dolor de cabeza (general)Científico

  A pilot trial comparing Pycnogenol plus standard therapy versus standard therapy alone in women with primary Raynaud's found significant improvements in blood flow, tissue oxygen levels, symptom scores (coldness, burning pain, paresthesia, color changes), and reduced oxidative stress biomarkers. A non-blinded preliminary study (Hu, Minerva Cardioangiol 2019) also showed reduced pain, discoloration, and increased finger temperature. ConsumerLab and Examine.com confirm Pycnogenol among supplements with demonstrated blood flow improvements for Raynaud's.

• Costra lácteaCientífico

  Pycnogenol (French maritime pine bark extract, standardized to ≥70% procyanidins) has been evaluated in randomized controlled trials for skin aging. An RCT of 75 mg/day oral Pycnogenol in postmenopausal women showed significant improvements in skin elasticity and hydration. It inhibits collagenase (MMP-1) and elastase, supporting dermal ECM preservation.

• Calambres (pierna)Científico

  Pycnogenol (standardized French maritime pine bark extract) has clinical evidence for improving skin elasticity and hydration in postmenopausal women, with corresponding increases in collagen type I and hyaluronic acid synthase gene expression in skin biopsies. A 12-week study of 20 postmenopausal women confirmed these findings via biophysical assessment and PCR analysis of skin biopsies.

• CortesCientífico

  Pycnogenol (French maritime pine bark extract) has multiple clinical studies specifically addressing spider veins (telangiectasias) and chronic venous insufficiency. Studies show it reduces spider vein clustering, size, and post-sclerotherapy skin discoloration, and it outperforms diosmin/hesperidin in reducing edema in some trials. Over 25 vein-specific studies have been conducted with this proprietary extract.

• QuistesCientífico

  Pycnogenol (French maritime pine bark extract) is a proanthocyanidin-rich extract with clinical and mechanistic evidence for UV photoprotection. A 30-day clinical trial in 30 women with melasma showed Pycnogenol (75 mg/day) significantly reduced melasma area and pigmentary intensity. A review of clinical and molecular evidence concluded Pycnogenol intake provides photoprotection, reduces hyperpigmentation, and improves skin barrier function.

• DiabetesCientífico

  Pycnogenol is the standardized French maritime pine bark extract (Pinus pinaster) with robust clinical evidence for CVI and varicose veins. Multiple RCTs show it reduces leg edema, improves venous tone, and outperforms diosmin-hesperidin and grape leaf extract for CVI symptom relief. A 98-subject RCT found 150 mg/day for 8 weeks significantly reduced ankle swelling and CVI scores. A meta-analysis showed a mean difference of 25.30 in pain reduction vs. standard therapy. It also slows varicose vein progression and promotes venous ulcer healing.

• Sarpullido por pañalCientífico

  Pycnogenol (French maritime pine bark extract) contains procyanidins and phenolic acids with antiviral and immunomodulatory properties. Clinical studies demonstrate it reduces the frequency and severity of influenza and respiratory infections. It enhances NK cell activity and modulates cytokine responses during viral challenge.

Sistemas corporales que Pycnogenol puede ayudar a apoyar.

• No hay sistemas corporales disponibles.