Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Licorice root (Glycyrrhiza glabra) has a long history of use in traditional medicine systems, particularly in Asia, for the treatment of respiratory illnesses, including influenza. In recent years, there has been growing scientific interest in its antiviral properties. Several in vitro (cell culture) studies have demonstrated that glycyrrhizin, a principal active component of licorice root, exhibits inhibitory effects against a range of viruses, including influenza A virus. These effects appear to be mediated by interference with viral replication and modulation of the host’s immune response, such as reducing pro-inflammatory cytokines. Some animal studies have shown that licorice extracts may reduce lung damage and viral loads following influenza infection.

However, clinical evidence in humans is limited. There are few, if any, well-designed human clinical trials directly assessing licorice root or its extracts for the treatment or prevention of influenza. Most human data comes from broader studies on respiratory infections or from traditional use reports. Safety is also a concern with prolonged use or high doses, as glycyrrhizin can cause side effects like hypertension and hypokalemia. In summary, while laboratory and animal data suggest potential antiviral and immunomodulatory benefits, the lack of robust clinical trials means that the scientific evidence supporting the use of licorice root for influenza remains preliminary (rated 2 out of 5).

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