Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Licorice root (Glycyrrhiza glabra) has been traditionally used in various systems of medicine, such as Traditional Chinese Medicine and Ayurveda, to treat infections and inflammatory conditions. However, beyond its traditional use, modern scientific research has demonstrated that licorice root contains several bioactive compounds—most notably glycyrrhizin and liquiritigenin—that exhibit antimicrobial, antiviral, and anti-inflammatory properties. In vitro studies have shown that glycyrrhizin can inhibit the replication of certain viruses, including hepatitis viruses and herpes simplex virus. Additionally, licorice extracts have demonstrated antibacterial effects against some Gram-positive and Gram-negative bacteria, though these effects are generally modest compared to standard antibiotics.

Despite these promising findings, most of the evidence comes from laboratory research or animal models, with fewer high-quality clinical trials in humans. Some small studies have suggested potential benefits in treating peptic ulcers and upper respiratory tract infections, but larger, well-controlled studies are lacking. Overall, licorice root’s use for infection is supported by both tradition and emerging scientific data, particularly for viral infections, but the clinical evidence remains preliminary. Caution is needed due to potential side effects, especially with long-term or high-dose use, such as hypertension and hypokalemia.

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