Evidence supporting the use of: Maltodextrin
For the health condition: Dehydration

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Maltodextrin is scientifically validated as a component of oral rehydration solutions (ORS) used to treat and prevent dehydration, particularly in cases of diarrhea or excessive fluid loss. The use of maltodextrin, a polysaccharide derived from starch, in rehydration therapy is based on the principles of glucose-mediated sodium and water absorption in the small intestine. Traditionally, ORS formulations included simple sugars like glucose. However, research has demonstrated that complex carbohydrates such as maltodextrin can be equally or more effective in facilitating water and electrolyte absorption.

Numerous clinical studies have shown that ORS containing maltodextrin are effective in rehydrating patients, especially children with acute diarrhea. Maltodextrin-based ORS has a lower osmolality compared to some glucose-based solutions, which can reduce the risk of osmotic diarrhea and improve overall fluid absorption. The World Health Organization (WHO) and UNICEF endorse the use of glucose-based ORS, but maltodextrin is often used in commercial and hospital formulations, supported by randomized controlled trials and meta-analyses.

In summary, maltodextrin's inclusion in rehydration solutions is grounded in scientific evidence demonstrating its efficacy in aiding water and electrolyte absorption, improving patient outcomes in dehydration. Its use is not merely traditional but is firmly supported by modern clinical research and physiological understanding.

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