Evidence supporting the use of: Ginseng
For the body system: Adrenal Glands

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Ginseng, particularly Panax ginseng and Panax quinquefolius (American ginseng), has been used in traditional medicine systems—most notably Traditional Chinese Medicine (TCM)—for centuries as an adaptogen, a substance believed to help the body resist stress and support overall vitality. In TCM, ginseng is thought to replenish "Qi" (vital energy) and is often recommended for fatigue, weakness, and to strengthen the body's response to physical and mental stress, which aligns conceptually with supporting the adrenal glands (organs responsible for stress hormone production).

While there are some modern studies exploring ginseng's effects on fatigue, cognitive function, and stress, direct scientific validation for its specific action on adrenal gland function (such as modulating cortisol or other adrenal hormones) remains limited. Most available evidence focuses on ginseng’s general adaptogenic and anti-fatigue properties, rather than a targeted adrenal support effect. A few animal studies suggest possible modulation of the hypothalamic-pituitary-adrenal (HPA) axis, but robust, high-quality clinical trials in humans specifically examining adrenal outcomes are lacking.

In summary, ginseng’s use for adrenal support is primarily justified by traditional use, with moderate supportive evidence for its adaptogenic effects, but limited direct scientific validation for targeted adrenal gland function.

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