Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Licorice root (Glycyrrhiza glabra) has a long history of use in traditional medicine systems such as Traditional Chinese Medicine (TCM) and Ayurveda, but there is also scientific basis for its use in supporting adrenal cortex function. The key active compound, glycyrrhizin, inhibits the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which leads to increased levels of endogenous cortisol by preventing its conversion to cortisone. This mechanism can result in mild cortisol-sparing effects and is the rationale for its inclusion in some adrenal support supplements. Several studies and reviews suggest that licorice root may help alleviate symptoms of adrenal insufficiency and fatigue by prolonging cortisol activity in the body (Armanini et al., 2012). However, the evidence is moderate, primarily based on small clinical studies and mechanistic research, rather than large-scale clinical trials. Additionally, prolonged use of licorice can lead to adverse effects such as hypertension and hypokalemia due to its mineralocorticoid-like activity. In summary, while there is a scientific rationale and some supporting evidence for licorice root’s role in supporting adrenal cortex function, the evidence is not robust and caution is warranted with its use.

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Other ingredients that support Adrenal Cortex

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