Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Medium chain triglycerides (MCTs) are scientifically validated for supporting small intestine function, particularly in individuals with malabsorption disorders or compromised digestive capacity. MCTs are composed of fatty acids with chain lengths of 6–12 carbons, such as caprylic (C8) and capric (C10) acids. Unlike long-chain triglycerides (LCTs), MCTs are more water-soluble, allowing them to be absorbed directly from the small intestine into the portal circulation without requiring bile salts for emulsification or pancreatic lipase for digestion.^[1] This property makes MCTs especially valuable in clinical nutrition for patients with conditions like short bowel syndrome, pancreatic insufficiency, or other malabsorptive states.^[2] Studies have demonstrated that MCT supplementation can improve fat and calorie absorption in these populations, helping to maintain nutritional status and body weight.^[3]

Beyond their use in malabsorption, there is limited evidence suggesting MCTs may have antimicrobial effects against certain intestinal pathogens and could modestly support gut barrier function, though these uses are less established.^[4] Overall, the primary scientific justification for MCT use in relation to the small intestine is to improve fat absorption in individuals whose intestines cannot efficiently process standard dietary fats.

• 1. Bach AC, Babayan VK. Medium-chain triglycerides: an update. Am J Clin Nutr. 1982;36(5):950-962.
• 2. Marten B, Pfeuffer M, Schrezenmeir J. Medium-chain triglycerides. Int Dairy J. 2006;16(11):1374-1382.
• 3. Nair KS, Halliday D, Garrow JS. Effect of medium-chain triglyceride on weight loss and nitrogen balance in obese subjects. Clin Sci. 1983;65(1):79-86.
• 4. Isaacs CE, et al. Inactivation of enveloped viruses in human bodily fluids by purified lipids. J Nutr Biochem. 1995;6(9):489-495.

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