Protease enzymes have been explored for their potential benefits in supporting exercise recovery and performance, particularly due to their ability to aid in protein digestion and modulate inflammation. Some studies suggest that protease supplementation can reduce markers of muscle damage (e.g., creatine kinase levels) and improve recovery following intense exercise. For example, limited clinical trials have noted reduced muscle soreness and faster strength recovery in athletes taking protease blends compared to placebo. Proposed mechanisms include enhanced breakdown of inflammatory mediators and support for muscle tissue repair through improved protein utilization.

However, the scientific evidence is mixed and relatively limited in scope. Most studies are small, short-term, and sometimes funded by supplement manufacturers, which raises questions about bias and generalizability. Systematic reviews and meta-analyses have yet to firmly establish the effectiveness of protease enzymes for exercise recovery or performance, and major sports nutrition organizations do not currently recommend their use as standard practice. There is some biological plausibility, and early results are promising, but robust, independent research is lacking.

In summary, while there is some scientific investigation into the use of protease enzymes for exercise support, the quality and quantity of evidence is moderate at best. The evidence does not yet rise to the level of strong, well-validated support, warranting a cautious approach to supplementation in this context.