Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (ascorbic acid) has been investigated as an adjunct to antibiotics or as a potential alternative in combating bacterial infections. The scientific rationale stems from its well-known antioxidant properties and its role in immune function. Experimental studies, particularly in vitro and in animal models, have demonstrated that vitamin C can inhibit the growth of certain bacteria, enhance the activity of phagocytes, and potentially disrupt biofilms that protect bacteria from antibiotics. Some studies suggest that vitamin C may reduce the minimum inhibitory concentration (MIC) of antibiotics against resistant bacteria, making antibiotics more effective. Additionally, vitamin C's immune-boosting effects might help the body clear infections more efficiently. Clinical studies in humans, however, are limited and often yield mixed results. A few small trials have explored vitamin C as an adjunctive therapy in infections like tuberculosis and sepsis, with some reporting reduced oxidative stress or improved clinical outcomes, while others show no significant benefit. There is not enough robust evidence to recommend vitamin C as a standalone alternative to antibiotics for treating bacterial infections. Instead, its use is best considered as a supportive measure rather than a replacement for standard antibiotic therapy. Overall, the current scientific evidence supports a potential adjunctive role for vitamin C, especially in specific cases or populations, but does not validate its use as a primary alternative to antibiotics. More high-quality, large-scale clinical trials are needed to clarify its effectiveness in this context.

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