Evidence supporting the use of: Black walnut
For the health condition: Antibiotics (alternatives to)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Black walnut (Juglans nigra) has a long history of traditional use in North American herbal medicine, especially among Indigenous peoples and early settlers. It has been used primarily for its purported antimicrobial and antiparasitic properties, most notably for treating intestinal worms, fungal infections (such as athlete’s foot), and skin conditions. The hulls, in particular, contain juglone, a compound known to exhibit some antimicrobial effects in vitro. Traditional herbalists have therefore sometimes recommended black walnut as a natural alternative or adjunct to conventional antibiotics, especially before the widespread availability of modern pharmaceuticals.

Despite these traditional uses, robust scientific evidence supporting black walnut as an effective alternative to antibiotics is limited. Laboratory studies have shown that extracts of black walnut hulls may have inhibitory effects against certain bacteria and fungi. However, there are no well-conducted clinical trials in humans demonstrating that black walnut can reliably treat bacterial infections, nor is there evidence it can replace prescribed antibiotics for serious conditions. Most evidence remains anecdotal or based on in vitro (test tube) studies, which do not always translate to effectiveness or safety in people. In summary, black walnut’s use as an antibiotic alternative is rooted in tradition, with only modest scientific support, and should not be considered a substitute for medical treatment when antibiotics are indicated.

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