Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Synopsis: Berberine, an isoquinoline alkaloid extracted from various plants such as Berberis vulgaris, has been studied for its cardiovascular effects, including potential benefits in angina pectoris. Scientific interest in berberine as a supportive agent for angina is based on its multiple pharmacological actions. Some clinical studies (mostly from China) have reported that berberine can improve symptoms of angina, enhance exercise tolerance, and reduce the frequency of angina attacks. These effects are thought to be mediated by berberine’s abilities to improve endothelial function, decrease oxidative stress, and exert anti-inflammatory effects. Additionally, berberine has demonstrated antiarrhythmic properties and positive inotropic effects, which can be beneficial for ischemic heart conditions such as angina.

However, the quality of evidence is moderate at best. While preliminary clinical trials and animal studies suggest beneficial effects, most available studies are small, lack rigorous controls, or are not published in widely accessible peer-reviewed journals. There are also no large-scale, high-quality randomized controlled trials (RCTs) in Western populations to confirm its efficacy and safety specifically for angina. Thus, while there is some scientific rationale and limited clinical data supporting the use of berberine in angina, stronger evidence is needed before it can be recommended as a standard therapy.

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