Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Licorice root (Glycyrrhiza glabra) has a long history of use in traditional medicine, but its application for Addison’s Disease (primary adrenal insufficiency) also has a scientific rationale. The active compound in licorice root, glycyrrhizin, inhibits the enzyme 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2). This enzyme normally converts active cortisol into inactive cortisone in the kidneys. By inhibiting this enzyme, glycyrrhizin can increase the availability and prolong the activity of cortisol in the body, which may theoretically help compensate for the cortisol deficiency in Addison’s Disease.

Historically, licorice root was used before synthetic corticosteroids became available, particularly in the early 20th century. Some case reports and early studies suggested that licorice could reduce the dosage of corticosteroid medications required in Addison’s Disease patients. However, the effect is modest and non-specific, and its use is limited by the risk of serious side effects, including hypertension, hypokalemia, and edema, due to mineralocorticoid-like activity.

Modern clinical management of Addison’s Disease relies on precise hormone replacement, and licorice root is not recommended due to its side effect profile and the availability of safer, more effective treatments. The scientific evidence supporting licorice root for Addison’s Disease is weak (rated 2/5); its use is of historical interest but is not endorsed by current guidelines.

More about licorice root
More about Addison's Disease

Other ingredients used for Addison's Disease

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