Evidence supporting the use of: Relora® (proprietary)
For the health condition: Worry

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Relora® is a proprietary blend of extracts from Magnolia officinalis and Phellodendron amurense, promoted for its ability to reduce stress and feelings of worry or anxiety. There is some scientific evidence supporting its use for reducing subjective feelings of stress and occasional anxiety. Several small, double-blind, placebo-controlled studies have investigated Relora®'s effects in adults experiencing mild stress or anxiety. These studies generally report that Relora® supplementation over several weeks can reduce self-reported stress, improve mood, and lower cortisol levels compared to placebo. However, the total number of studies is limited, sample sizes are small (often less than 100 participants), and trials are typically short in duration (2–6 weeks).

The mechanism of action is believed to involve modulation of the hypothalamic-pituitary-adrenal (HPA) axis and GABAergic neurotransmission, which may help counteract the physiological and psychological effects of stress. Magnolia officinalis bark contains honokiol and magnolol, compounds shown in preclinical studies to have anxiolytic-like effects. While these findings are promising, there are gaps in the evidence: studies are short-term, there is a lack of large-scale independent replication, and most research has focused on general stress or tension rather than clinically diagnosed anxiety disorders. Nonetheless, Relora® is sometimes used as an adjunct to lifestyle management of mild worry or stress.

In summary, there is preliminary scientific evidence for Relora®’s use in supporting stress and worry, but the strength of evidence is moderate to low (rated 2 out of 5), and further research is needed to confirm its efficacy and safety for this purpose.

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