Evidence supporting the use of: Perilla
For the health condition: Wheezing

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Perilla (Perilla frutescens), known as "zi su" in traditional Chinese medicine (TCM), has a long-standing history of use for respiratory conditions, including wheezing, cough, and asthma-like symptoms. In TCM, perilla leaf is often prescribed as part of herbal formulas to "disperse wind-cold," "transform phlegm," and "regulate qi," which are believed to help in relieving symptoms such as coughing and wheezing. Classic TCM texts describe its use for "coughing and wheezing with copious phlegm," and it is commonly combined with other herbs such as ephedra (ma huang) and licorice (gan cao) for respiratory support. Modern scientific research on perilla regarding its effects on wheezing or asthma is limited but growing. Some studies have suggested that perilla extracts possess anti-inflammatory, anti-allergic, and bronchodilatory effects in animal models, which could theoretically be beneficial for airway inflammation and bronchospasm that underlie wheezing. Compounds such as perilla aldehyde and rosmarinic acid may play a role in modulating allergic responses. However, robust clinical trials in humans specifically targeting wheezing or asthma are lacking, and current evidence does not meet the threshold for strong scientific validation. In summary, perilla’s use for wheezing is primarily justified by traditional practices, with some preliminary scientific indications that warrant further research. The evidence level is moderate based on historical use, but low from a rigorous scientific perspective.

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