Evidence supporting the use of: Vitamin B12
For the health condition: Wasting

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin B12 is scientifically used in the treatment or support of wasting, particularly when wasting is related to underlying B12 deficiency. Wasting—characterized by unintended weight loss, muscle atrophy, and weakness—can be caused by various conditions, including malnutrition, chronic illness, and malabsorption syndromes. Vitamin B12 is essential for DNA synthesis, red blood cell formation, and proper neurological function. Deficiency in B12 can lead to megaloblastic anemia, neuropathy, and general weakness, all of which may contribute to or exacerbate wasting. Clinical studies have shown that individuals with B12 deficiency—including those with pernicious anemia, gastrointestinal disorders (such as Crohn’s disease or celiac disease), or after certain types of bariatric surgery—often experience muscle weakness, fatigue, and weight loss. Supplementation with B12 in these cases has been shown to reverse hematological and neurological abnormalities and improve overall nutritional status, which can mitigate symptoms of wasting. However, in individuals without B12 deficiency, supplementation has not been shown to treat or prevent wasting. Therefore, while B12 is not a universal treatment for all causes of wasting, there is solid scientific evidence supporting its use in cases where wasting is associated with a deficiency of this vitamin. Routine use of B12 for wasting in the absence of deficiency is not supported by current scientific literature.

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