Hesperidin is a flavonoid predominantly found in citrus fruits, and its use to support the venous system is backed by scientific evidence. It is commonly included in micronized purified flavonoid fraction (MPFF) formulations, often combined with diosmin, for the management of chronic venous insufficiency (CVI) and related symptoms such as varicose veins and leg swelling. Multiple randomized controlled trials and meta-analyses have demonstrated that hesperidin-containing preparations improve venous tone, reduce capillary permeability, and decrease inflammation, which leads to symptom relief in CVI patients. European guidelines for the management of chronic venous disorders support the use of MPFFs, highlighting moderate to strong evidence for their efficacy in reducing symptoms like leg heaviness, pain, and edema.

The mechanisms proposed for hesperidin’s efficacy include its antioxidant properties, ability to inhibit leukocyte activation, and improvement of lymphatic drainage. Safety profiles reported in the literature are favorable, with minimal adverse effects. While some studies use hesperidin alone, most of the robust clinical evidence comes from combination products with diosmin; thus, the strength of evidence for hesperidin alone, while significant, is somewhat less definitive. Nevertheless, the overall body of research provides scientific validation for hesperidin’s use in supporting the venous system, especially in the context of chronic venous disorders.