Evidence supporting the use of: DHEA (dehydroepiandrosterone)
For the body system: Testosterone

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHEA (dehydroepiandrosterone) is a steroid hormone naturally produced by the adrenal glands and serves as a precursor to both androgens (including testosterone) and estrogens. Its use as a supplement to support testosterone levels is based on its role in the body's steroidogenic pathway. There is some scientific evidence suggesting that DHEA supplementation can increase serum testosterone levels, particularly in populations with low baseline DHEA, such as older men and women or individuals with adrenal insufficiency. However, the effects are generally modest, and results across studies are inconsistent.

Clinical studies have shown that DHEA supplementation may slightly increase testosterone in elderly men and women, but the effect is less pronounced or absent in healthy, young men. The Endocrine Society and other medical organizations do not recommend DHEA supplementation for healthy individuals due to insufficient evidence of benefit and potential adverse effects. Additionally, long-term safety data is limited, and concerns exist regarding hormone-sensitive cancers and other side effects. In summary, while there is a scientific rationale and some supportive evidence, the overall strength of evidence for DHEA as a testosterone booster is limited, and its use remains controversial in mainstream medicine.

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