Evidence supporting the use of: Magnesium
For the body system: Testes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Magnesium is involved in numerous physiological processes, including those critical to male reproductive health and the function of the testes. Scientific evidence indicates that magnesium plays a role in testosterone production, spermatogenesis, and overall testicular function. Research has shown that magnesium deficiency can negatively affect testosterone levels and sperm quality. For example, some studies have observed that supplementation with magnesium can increase free and total testosterone, particularly when combined with exercise. Additionally, magnesium is a cofactor for enzymes involved in steroidogenesis, the process by which steroids such as testosterone are produced in the testes. However, while there is moderate evidence supporting the importance of magnesium for general testicular health and hormonal balance, robust clinical trials specifically targeting male fertility or testicular disorders using magnesium supplementation are limited. The evidence is stronger for magnesium’s indirect support—by reducing oxidative stress, improving vascular function, and supporting overall endocrine health—rather than for direct, targeted effects on the testes alone. Therefore, while scientific rationale and some supporting studies exist, the overall level of evidence is moderate, not high, and further research is warranted to clarify the extent of magnesium’s benefits specifically for the testes.

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