Evidence supporting the use of: Magnesium
For the body system: Structural System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Magnesium is scientifically validated as an important mineral for supporting the structural system, particularly bone health. Approximately 60% of the body’s magnesium is stored in bone, where it contributes to bone mineralization and structural development. Research has shown that magnesium deficiency is associated with lower bone mass, osteoporosis, and increased fracture risk. Magnesium acts as a cofactor for enzymes involved in bone formation, influences the activity of osteoblasts and osteoclasts, and plays a role in regulating calcium and vitamin D metabolism—all crucial for maintaining bone density and strength.

Clinical studies have found that adequate magnesium intake is linked to higher bone mineral density in both men and women, especially older adults. Supplementation in deficient populations has been shown to improve bone turnover markers and may help slow bone loss. While calcium and vitamin D are often emphasized for bone health, magnesium’s role is increasingly recognized as essential and synergistic. Most evidence comes from epidemiological studies and randomized controlled trials examining magnesium’s impact on bone health and fracture risk. The evidence is robust, although not all studies show benefit with supplementation outside of deficiency states. Overall, magnesium’s use for supporting the structural system, particularly bone health, is strongly supported by scientific evidence.

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