Evidence supporting the use of: Vitamin B12
For the health condition: Stress

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B12 is an essential vitamin involved in numerous metabolic processes, notably the production of red blood cells, DNA synthesis, and neurological function. The use of vitamin B12 to support or treat "stress" is somewhat scientifically grounded, though the evidence is limited and indirect. B12 deficiency can lead to neurological symptoms such as fatigue, irritability, and mood disturbances, which can mimic or exacerbate feelings of stress. Several studies have shown that individuals with low B12 levels are more likely to experience mood disorders, including depression and anxiety, which are often intertwined with stress. Supplementation in deficient individuals can improve energy levels and mood, potentially helping them cope with stress more effectively.

However, there is insufficient direct evidence that vitamin B12 supplementation reduces stress in individuals who are not deficient. Most scientific support revolves around the correction of deficiency, not the direct alleviation of everyday psychological stress in otherwise healthy individuals. Thus, while there is a scientific rationale for ensuring adequate B12 intake to support mental and neurological health, the direct use of B12 supplements as a treatment for stress is only weakly supported by current evidence, warranting a modest evidence rating.

More about vitamin B12
More about Stress

Other ingredients used for Stress

5-Hydroxytryptophan (5-HTP)
7,8-Dihydroxyflavone
7-Keto-DHEA
Acetyl L-carnitine
Acetyl-L-Tyrosine
Agarwood
Agastache
Agmatine
Agrimony
Akebia
Albizia
Algal protein
Alpha lactalbumin
alpha-pinene
AMP-activated protein kinase (AMPK)
anemarrhena asphodeloides
anise
Anserina
antler
Antrodia camphorata
apigenin
Aralia
Arginine aspartate
arjun tree
arjuna
ashitaba
ashwagandha
asparagus
astragalus
baccosides
Bacopa
Bacopin
bacoside
baicalein
baicalin
Baikal Skullcap
banana
banyan
Basidiomycota
bee pollen
benegut perilla (proprietary)
bergamot
betony
Bifidobacteria
Bifidobacterium bifidum
Bifidobacterium lactis
Bifidobacterium longum
biota seed
bird\'s nest
black ginger
Black spruce
black tea
bonito peptide
borage
brahmi
Buddha\'s hand
Bupleurum
bupleurum falcatum
C-phycocyanin
calamus
Calea zacatechichi
California poppy
Canscora
Capitate Valerian
cardamom
caterpillar mushroom
catnip
catuaba
Celastrus
Centella asiatica
Centella triterpenes
chaga mushroom
chamomile
cherimoya
Chinese fleeceflower
Chinese mountain ant
chocolate
chuchuhuasi
Clary sage
Clerodendrum phlomidis
coca
cocoa
Codonopsis
Convolvulus pluricaulis
Convolvulus prostratus
cordyceps
coriander
corktree
Corydalis
cowslip
curcumin
Cymbopogon martini
cypress
damiana
date
devil\'s club
DHA (docosahexaenoic acid)
dibenzo-alpha pyrones
dismutase
dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide
dodeca-2E, 4E-dienoic acid isobutylamide
dong quai root
eleuthero
emblicanin
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
Eplotab
Erythrina
Eurycoma Longifolia
Ficus religiosa
fish
fish protein
flavones
fo-ti
fragrant rosewood
frankincense
Fumaria parviflora
GABA (gamma aminobutyric acid)
galactooligosaccharides
gardenia
gastrodin
Gelsemium
Ginsenosides
Glycine
goji berry
goldthread
gotu kola
green tea
Griffonia simplicifolia
guayusa
gum
heartwood
Hemidesmus
hericium mushroom
hibiscus
Homalomena
honeybush
Honokiol
hops
Hypericum
isoliquiritigenin
Japanese kadsura
jasmine
Jatamansi
jiaogulan
jujube
jujubosides
kanna
kava
kavalactones
kola nut
kuding tea
kudzu
Kukicha
L-ornithine
L-taurine
L-theanine
L-tryptophan
l-tyrosine
lactalbumin
lactiplantibacillus plantarum
lactium casein decapeptide
Lactobacillus brevis
Lactobacillus casei
Lactobacillus helveticus
Lactococcus rhamnosus
Lactucarium
Lactucopicrin
Large-leaved linden
Lavandin
lavender
lemon balm
Lentinula edodes mycelia
Leptadenia
limonene
linden
lingzhi
lion's mane
liquid liver fractions
longan
lotus
lupulinum
Lycium
maca
macaenes
macamides
magnesium
magnolia
magnolol
mandarin
mangiferin
maral root
Marjoram
Matcha
Mate
Meadow sage
Melatonin
Mentha haplocalyx
Mesembrine
Methylxanthine
Mimosa
Mimulus
Mint
Mistletoe
Monkey flower
Motherwort
Muira puama
Mulberry
Mulungu
Mung bean
Myrcene
Nardostachys
Night jessamine
noni
Nymphaea caerulea
oat
oolong tea
orchid
oriental arborvitae
Oxindole alkaloids
passionflower
Passionfruit
Patchouli oil
Pentatropis capensis
Pepper Bark Tree
Peppermint
perilla
phosphatidylserine
phospholipids
pine bark
Piper chaba
Pistachio
Polygala
polygala root
poppy
pregnenolone
Purple Monkeyflower
pyrroloquinoline disodium salt
pyrroloquinoline quinone
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Rauvolfia
Rehmannia
relora® (proprietary)
Rhodiola
Rooibos
Rosabin
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rose
rose oil
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Safranal
Salidroside
Sandy Everlasting
Sarivan
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sceletium
Schisandrins
Schizandrol A
Scleranthus annus
Semecarpus anacardium
sesame
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Shilajit
Sida cordifolia
silk tree
skullcap
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Speedwell
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spinach
St. John's Wort
Stachytarpheta cayennensis
star of Bethlehem
suma
Sumbul
Sweet Woodruff
Tagara
Taurine
Taxillus chinensis
Tetracyclic oxindole alkaloids
Tetrahydropalmatine
Traveler's Joy
Trichilia catigua
Trichopus zeylanicus
Uncaria
Valerenic acid
Valerian root
Vanilla
velvet bean
Verbena
Vetiver
Viburnum
Vine tea
vitamin B12
vitamin B6
Vitexin
Waterhyssop
whole adrenal glandular
Withanolides
Wogonin
Wood betony
Xanthine
Xanthone
Xanthophyll
Xylaria nigripes
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Yerba mate
Ylang ylang
Yohimbine
Yumberry
Yuzu
Zinc