Evidence supporting the use of: Folate
For the body system: Small Intestines

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Folate, also known as vitamin B9, is scientifically validated as essential for supporting the health and function of the small intestine, primarily through its role in cellular growth and repair. The small intestine has a rapid turnover of epithelial cells, and folate is crucial for DNA synthesis and cell division. Deficiency in folate can lead to villous atrophy and impaired nutrient absorption, as demonstrated in both human and animal studies. In conditions of malabsorption—such as celiac disease or inflammatory bowel diseases—folate deficiency is common, indicating a close relationship between folate status and small intestine health. Supplementation with folate can correct deficiency and improve mucosal health in these contexts.

Clinical guidelines often recommend folate supplementation for individuals with chronic gastrointestinal diseases that affect absorption. Research also shows that folate supports the maintenance and regeneration of the intestinal mucosa. However, while folate is critical for overall gut function, it should be noted that it is not a treatment for specific small intestine diseases but rather supports the tissue’s ability to repair and maintain itself. Thus, the scientific evidence is robust for folate's supportive role in the small intestine, particularly in preventing and correcting deficiency-related complications.

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