Evidence supporting the use of: Knotgrass (unspecified)
For the body system: Skin
Synopsis
Source of validity: Traditional
Rating (out of 5): 2
Knotgrass (Polygonum aviculare), while used in various traditional medicine systems, is primarily supported by ethnobotanical and historical practices rather than robust scientific evidence, especially for skin health. In traditional European and Asian herbalism, knotgrass has been used topically and internally for its purported anti-inflammatory, astringent, and wound-healing properties. Herbalists have applied it to minor wounds, skin irritations, and as a wash for promoting healthy skin. These uses rest on the plant’s content of flavonoids, tannins, and other phenolic compounds, which are thought to contribute to its astringent and antimicrobial actions.
However, scientific studies directly investigating knotgrass for skin-related outcomes are limited. Most research focuses on its antioxidant capacity and general anti-inflammatory effects in vitro or in animal models, rather than clinical trials in humans. There is no substantial clinical evidence to confirm its efficacy for specific skin disorders or to demonstrate meaningful benefit in topical or systemic use for skin health. Thus, while knotgrass is traditionally used to support the skin and contains bioactive compounds that may plausibly contribute to such effects, the evidence base is largely historical and anecdotal.
In summary, the use of knotgrass for skin health is justified primarily by tradition, with only weak to moderate indirect scientific support.
Other ingredients that support Skin
cutchacai berry
alfalfa
algal oil
aloe vera
alpha-carotene
alpha-glycosyl isoquercitrin
alpha-linolenic acid (ALA)
amino acids
annatto
anthocyanins
apple
apricot
ascorbyl palmitate
astaxanthin
barberry
barley
basil
bayberry
beeswax
myrobalan
bergamot
berry flavor
beta and delta tocopherols
beta caryophyllene
beta-carotene
beta-tocopherol
biotin
bisabolol
black cumin
black currant
radish
sesame
black tea
black walnut
blackberry
borage oil
Indian frankincense
bovine
bovine gelatin
bovine liver
broccoli
rice
brussel sprouts
burdock
cabbage leaf
camu camu
cannabis sativa oil
canola oil
capsaicinoids
carrot
catechins
ceramides
chamomile
cherry
chia seed
chlorella
chokeberry
citrus oil
citrus sinensis (proprietary)
clove
coconut milk
coenzyme Q10 (CoQ10)
collagen
collard
colostrum
copper
cottonseed oil
Coptis chinensis
cryptoxanthin
cucumber
turmeric
curcumin
cuspidatum root
d-alpha tocopherol
dandelion
delta-tocopherol
DHA (docosahexaeonic acid)
dog rose
DPA (docosapentaenoic acid)
melon
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
evening primrose oil
fennel
fenugreek
fish oil
fish protein
flavonols
flaxseed
forsythia
fruit and vegetable blend (proprietary)
fruit blend (proprietary)
gamma linolenic acid (GLA)
gamma tocopherol
gardenia
gelatin
genistein
glycerin
glycitin
goldenseal
gooseberry
gotu kola
grape
green tea
greens blend (proprietary)
guggul
hemp oil
hibiscus
horsetail
hyaluronic acid
honeysuckle
knotweed
Japanese sophora
jujube
kale
kelp
l-carnosine
l-cysteine
l-cystine
l-glutathione
l-glycine
l-histidine
l-lysine
l-methionine
l-proline
lactobacillus reuteri
lactobacillus rhamnosus
lactoferrin
lauric acid
lavender
lemon
licorice root
linoleic acid (LA)
luteolin
lychee
lycopene
mackerel
magnesium
manganese
mango
mangosteen
maqui berry
marine lipid
marshmallow
matcha
melatonin
methylsulfonylmethane (MSM)
milk
mixed carotenoids
moringa
mustard seed
nettle
niacin (vitamin B3)
niacinamide (vitamin B3)
nicotinamide riboside
oat
okra
oleanolic acid
oleic acid
olive
omega-3 fatty acids
omega-6 fatty acids
omega-7 fatty acids
omega-9 fatty acids
orange
oregon grape
PABA (para-aminobenzoic acid)
palmitate
palmitoleic acid
pantothenic acid (vitamin B5)
parsley
perilla
phellodendron amurense
phenolic acids
phosphatidylcholine
phospholipids
phytocannabinoids
pine bark
plantain
plum fruit
polypeptide complex (proprietary)
pomegranate
pomelo
protein
pumpkin
quercetin
raspberry
resveratrol
rhizome
riboflavin (vitamin B2)
rose hips
rose oil
rosemary
safflower oil
saffron
sage
sardines
schizonepeta
scrophularia root
selenium
shrimp
silicon
slippery elm bark
sorbitol
soybean
specialized pro-resolving mediators (SPMs)
sphaeranthus indicus
spinach
spirulina
stearic acid
stevia
strawberry
succinic acid
sulforaphane glucosinolate
thyme
tocotrienols
tomato
triphala
almond fruit
ubiquinol
undecylenic acid
vegetable and fruit blend (proprietary)
vitamin A
vitamin B
vitamin C
vitamin D
vitamin D3
vitamin E
seaweed
water
watercress
watermelon
mulberry
yeast
zinc
β-nicotinamide mononucleotide (NMN)
sarsaparilla
red clover
yellow root
chickweed
tangerine
papaya
mugwort
Indian bael
neem tree
nut grass
clerodendrum indicum
hedychium spicatum
commiphora
holarrhena antidysenterica
smilax
caesalpinia crista
fumaria parviflora
rubia cordifolia
swertia
bee pollen
chaff flower
lingzhi
goldenrod
yarrow
pau d'arco
prickly ash
moss
morus
lemongrass
sunflower
myrrh
yerba santa
sodium salt
coltsfoot
ferulic acid
chrysanthemum
juniper berries
siler root
cistanche
ganoderma
morinda
oriental arborvitae
zanthoxylum
birch
dulse leaf
sheep's sorrel
royal jelly
Equol (proprietary)
queen of the meadow
polyphenols
trace minerals
anemarrhena asphodeloides
purslane
fulvic acid
yucca
wintergreen
camphor oil
menthol oil
coix
cleavers
stillingia
shepherd's purse
wheat germ
peach
noni
biota seed
nopal
goji berry
paw paw
white oak
amaranth
herbal blend (proprietary)
melaleuca alternifolia
algae
indigo leaves
cocoa
ashitaba
soursop
bladderwrack
geranium
arnica
sea salt
3,3'-dihydroxy-B-carotene-4,4'-dione
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Avens
Arjuna
Apple Cider Vinegar
Autumn elaeagnus
Alpha-terpineol
Asiaticoside
Azelaic acid
Ardisia
Angelica
Arachidonic Acid
Arbutin
Agrimony
Apigenin
Aronia melanocarpa
Anamu
Abrus
Alchornea
Albizia
Alchemilla
Aucubin
Avocado
Anserina
Aerva lanata
Alpha Hydroxy Acids
Anemone
Allantoin
Alpha-Lipoic Acid
Arrowroot
anthocyanidins
Adzuki bean
Alkanet
Alsonia scholaris
Agrimonia pilosa
Asteracea
Acemannan
Algal protein
anthocyanosides
Artemisia Anomala
Ashoka
Argan nut oil
Acinetobacter lwoffii
Alkanna
Amor seco
Arctiin
Astragalin
Animal protein
Bee Propolis
Black Seed
Buttermilk
Baikal Skullcap
Buglossoides arvensis
Biopeptide
Babchi
Bai Ji
Baliospermum
Baphicacanthus cusia
Bidens pilosa
Black spruce
Blackthorn
Broussonetia
beta-zeacarotene
Betulinic acid
Blepharis
Brown Algae
Balsam
Brassica
Bishop's Weed
Boswellic Acid
Belleric myrobalan
Bistort
Bran
Butea monosperma
Beef
Beef liver
Baccharis dracunculifolia
Barleria
Brazillian peppertree
Bisabolene
Bovine Protein
Bael
Bloodroot
Benzoin
Begonia fimbristipula
berry
Bogbean
Black Gram
Brazil nut
Black Poplar
Baccharoides anthelmintica
Banyan
Black willow
Bletilla
Bioflavonoids
black salt
Bee products
Black Nightshade
Bombax
Babassu
Borage
bovine cartilage / glycosaminoglycan
banana
Baobab
Bittersweet
Baicalin
Buckwheat
Bassia scoparia
Bee venom
Bignay
Boerhavia diffusa
Borneol
Bird's nest
Chia seed
Caffeic Acid
Comfrey
Camellia sinensis
Coconut
Centella triterpenes
Curry leaf
Calendula
Casearia esculenta
Common Monkey Flower
Cinnamomum
Clary sage
Chinese Mountain Ant
Cyanobacteria
Calotropis gigantea
Chervil
Cloudberry
Carnosine
Colloidal Silver
Chebulic acid
Chlorophyllin
Camelina Oil
coconut oil
Cod Liver Oil
Coriander
Cnidium
Clerodendrum phlomidis
Cactus
Cape Aloe
Cinquefoil
Cyanidin
Cocoa Butter
Chinese Fleeceflower
Curcuminoid
Citrus
Capsaicin
Cymbidium goeringii
Cornflower
Chinese Pond Turtle
Cajuput
Canaigre
Cancerina
Cantaloupe
Chuchuhuasi
Cruciferous
Chordaria cladosiphon
Catechu
Cymbopogon Martini
Centella asiatica
Coconut Water
Celandine
Ceylon Leadwort
Chocolate
Cissus sicyoides
Chinese Ligustrum berry
Cedar
Cinidium
Centipeda
Cistus
Corktree
Curcuma
Carnosol
C-Phycocyanin
Chaparral
Cabbage
Cowslip
Chirata
Cranesbill
Cannabidiol
Carlina
Carotene (unspecified)
Cedrus libani
Chestnut
Castile Soap
Connective tissue growth factor
Cynodon dactylon
Chiococca alba
Cystine
Cocklebur
Castor Oil
Carthamus
Copaiba Oil
Crypthecodinium
Celosia
Clerodendrum indicum
Cade Juniper
Canscora
Cupuacu
Casearia sylvestris
Currant
Carnosic acid
Cannabichromene
Cannabigerol
Chrysophanics
Chondrus
Dunaliella salina
Dismutase
Delphinidin
Dunaliella
DL-Methionine
Deer Root
Dehydroascorbic acid
Dumontiaceae
Dragon Fruit
Dihydrolipoic Acid
Dragonhead
Dragon's Blood
Devil's Club
Dihomo-gamma-linolenic acid
Date
Dwarf Nettle
Dulse
Dimethyl sulfoxide (DMSO)
Davilla rugosa
Dipsacus
Docosanol
Epidermal Growth Factor
epicatechin
E-Viniferin
Ellagic Acid
Erigeron
Egg
Eclipta
Erythrina
Ergothioneine
Echinacea
Emblicanin
Eicosatetraenoic acid
Elder
Emu Oil
Eucheuma
Eicosapentaenoic Acid
Essential Oil Blend
Euglena gracilis
Euphorbia
Evening Primrose
Ethyl Linoleate
Escin
Egg protein
Elemi
Elastin
Echium
Eugenol
Ecklonia
Fig
Fatty alcohol
Goldthread
Garlic
Glycine
Glycosaminoglycans
Himalayan Salt
jasmine
Lotus
Lily
Little ironweed
Mustard
Mallow
Milk Protein
Mimosa
Oak
Potato
Prickly Pear Cactus
Quince
Quinoa Protein
Rose
Spikenard
Snakeroot (unspecified)
Silk protein
Soy Protein
Sandalwood
Vervain
Vinegar
walnut
Other body systems supported by Knotgrass (unspecified)
BladderBlood
Digestive System
Gastrointestinal Tract
Heart
Immune System
Intestinal System
Joints
Kidneys
Liver
Lungs
Respiratory System
Skin
Urinary System