Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D is scientifically validated to play a role in supporting the respiratory system, though the evidence is moderate rather than definitive. Vitamin D receptors are expressed in many immune cells, and vitamin D is known to modulate both innate and adaptive immune responses. Deficiency in vitamin D has been associated with increased susceptibility to respiratory infections, such as influenza and other viral illnesses. Several observational studies have found that individuals with lower levels of vitamin D are more likely to suffer from acute respiratory tract infections. A notable 2017 meta-analysis in BMJ concluded that vitamin D supplementation can modestly reduce the risk of acute respiratory infections, particularly in individuals with low baseline vitamin D levels.

More recently, interest grew in the potential for vitamin D to mitigate the severity of COVID-19, with some studies suggesting a correlation between deficiency and worse outcomes, although results have been mixed and more research is needed. Mechanistically, vitamin D is thought to influence the respiratory system by enhancing the production of antimicrobial peptides in the lungs and reducing inflammatory responses that can damage lung tissue.

While there is a strong biological rationale and some clinical evidence for vitamin D’s supportive role in the respiratory system, especially for infection risk, the overall strength of the evidence is moderate. Supplementation is most clearly beneficial in those who are deficient, while the benefit in individuals with sufficient vitamin D status is less certain.

More about vitamin D
More about Respiratory System

Other ingredients that support Respiratory System

Other body systems supported by vitamin D

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