Evidence supporting the use of: DHEA (dehydroepiandrosterone)
For the body system: Reproductive System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

DHEA (dehydroepiandrosterone) is an endogenous steroid hormone produced by the adrenal glands, gonads, and brain, which serves as a precursor to both androgens and estrogens. Its use to support the reproductive system, particularly in the context of fertility and menopause, is based on some scientific research, though the evidence is mixed and not definitive. Several studies have explored DHEA supplementation in women with diminished ovarian reserve or those undergoing in vitro fertilization (IVF). Some small clinical trials and observational studies have reported that DHEA may improve ovarian response, increase the number of retrieved oocytes, and potentially enhance pregnancy rates in women with infertility related to low ovarian reserve. However, systematic reviews and meta-analyses note that the quality of evidence is generally low to moderate, and larger, well-designed trials are needed to confirm these benefits.

In men, DHEA supplementation has been studied for potential roles in improving erectile dysfunction and sperm parameters, but results are inconsistent. DHEA is also sometimes used to alleviate symptoms of menopause, such as decreased libido, due to its role as a precursor to sex hormones, though evidence here is also limited.

Overall, while there is some scientific basis for the use of DHEA to support reproductive health—particularly in women with specific fertility issues—the evidence is not robust, and routine use is not universally recommended by clinical guidelines. Medical supervision is advised due to possible side effects and hormonal alterations.

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