Nettle (Urtica dioica), particularly its root extract, is commonly used in Europe as part of phytotherapeutic approaches to support prostate health, including in cases of prostatitis and benign prostatic hyperplasia (BPH). The rationale for its use in prostatitis is primarily based on its anti-inflammatory, antioxidant, and mild antiandrogenic properties. Scientific studies, including randomized controlled trials and meta-analyses, have investigated nettle root both as a monotherapy and in combination with other herbs (most notably saw palmetto). Clinical trials suggest that nettle root may help improve lower urinary tract symptoms, which often overlap with symptoms of prostatitis, such as urinary frequency, urgency, and incomplete emptying. The primary mechanism is believed to involve inhibition of inflammatory mediators, modulation of sex hormone-binding globulin, and possible suppression of prostatic cell proliferation.

Despite these findings, most studies focus on BPH rather than specifically on prostatitis, and the available evidence for nettle's efficacy in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is limited but growing. Some small trials and observational studies report symptom improvement and decreased markers of inflammation. However, methodological limitations, small sample sizes, and variability in preparations used mean that evidence is moderate (rated 3/5). Therefore, while nettle has both a traditional and a growing scientific basis for use in supporting prostate health and possibly prostatitis, more targeted studies are required to firmly establish its role in prostatitis treatment.