Evidence supporting the use of: Folate
For the health condition: Pap Smear (abnormal)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Folate (vitamin B9) has some scientific support for its use in the context of abnormal Pap smears, particularly those indicating cervical dysplasia (such as low-grade squamous intraepithelial lesions, LSIL). Cervical dysplasia is a precancerous condition often caused by persistent infection with high-risk human papillomavirus (HPV). Folate is essential for DNA synthesis, repair, and methylation, and deficiency has been linked to increased risk of cervical dysplasia and persistence of HPV infection.

Several observational studies have found an association between low folate status and higher risk of cervical dysplasia and cancer. Some interventional studies suggest that folate (often in combination with other B vitamins) supplementation may help regress mild cervical lesions or reduce progression, especially in women with low baseline folate levels. For example, a randomized controlled trial published in 2016 in the journal Obstetrics & Gynecology found that daily folate supplementation for six months significantly increased regression of LSIL compared to placebo. However, results are not universally consistent, and benefits appear to be mostly limited to women who are deficient in folate.

Given this, folate supplementation is sometimes recommended alongside standard monitoring or treatment for mild cervical dysplasia, but it is not a substitute for regular gynecological follow-up or HPV vaccination. The evidence base is moderate: there is biological plausibility and some clinical trial support, but guidelines do not universally recommend it for all women with abnormal Pap smears.

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Other ingredients used for Pap Smear (abnormal)

curcumin
folate
indole-3-carbinol