Evidence supporting the use of: Magnesium
For the health condition: Pain (general remedies for)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Magnesium has been studied for its role in pain management, particularly in the context of chronic pain syndromes, migraine, and neuropathic pain. Scientific interest in magnesium stems from its role as a natural calcium antagonist and as a modulator of NMDA (N-methyl-D-aspartate) receptors, which are involved in pain transmission and central sensitization. Intravenous magnesium sulfate has been investigated for acute migraine attacks and postoperative pain, with some studies suggesting modest benefit in reducing pain intensity and opioid requirements. In chronic pain conditions such as fibromyalgia and neuropathic pain, data are mixed, with some small clinical trials and observational studies reporting symptom improvement, while others fail to show significant effects.

Overall, the evidence supporting magnesium’s use in general pain management is limited and inconsistent. Most studies are small, heterogeneous in design, and often lack rigorous controls. The strongest support exists for specific conditions like migraine and neuropathic pain rather than for general pain relief. Magnesium supplementation is generally considered safe when used appropriately, making it a low-risk adjunct in some individuals, especially those with documented deficiency. However, current clinical guidelines do not recommend magnesium as a first-line treatment for general pain, and more large-scale, high-quality studies are needed to clarify its efficacy and optimal use.

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Other ingredients used for Pain (general remedies for)

Allspice
alpha-pinene
arjun tree
ashwagandha
Waterhyssop
bamboo
barberry
Myrobalan
benegut perilla (proprietary)
beta caryophyllene
beta-pinene
betel
bisabolol
black pepper
radish
Indian frankincense
bromelain
bupleurum falcatum
burdock
cabbage leaf
California poppy
camu camu
cassia bark
celery
chen pi
cherry
Chinese salvia root
chymotrypsin
Cissus quadrangularis
collagen
cordyceps
turmeric
curcumin
devil's claw
diallyl disulfide (DADS)
diallyl trisulfide (DATS)
dog rose
ethanol
fennel
fenugreek
flaxseed
fruit blend (proprietary)
gelatin
ginger
gooseberry
gotu kola
honeysuckle
Japanese sophora
jujube
kudzu
L-phenylalanine
lovage
magnesium
Methylsulfonylmethane (MSM)
Mint
Nettle
spruce
okra
orange
Peppermint
perilla
polygala root
protease
pumpkin
quail egg
reishi mushroom
rose oil
rutin
saffron
sage
black ginger
specialized pro-resolving mediators (SPMs)
strawberry
vitamin D
Watercress
Mulberry
white willow
zhejiang fritillary
sarsaparilla
Yellow root
boneset
catnip
typhonium
hyssop
cardamom
atractylodes
alpinia galangal
Clerodendrum indicum
Hedychium spicatum
inula racemosa
anise
pistacia integerrima gall
paederia foetida
smilax
Fumaria parviflora
Rubia cordifolia
Swertia
chaff flower
Szechuan lovage
goldenrod
Yarrow
prickly ash
Morus
root tuber
silk tree
haliotis
juniper berries
solomon's seal
amber
flowering quince
cistanche
dioscorea
teasel
sweetgums
lotus seed
birch
queen of the meadow
anemarrhena asphodeloides
purslane
Yucca
barrenwort
Wintergreen
camphor oil
aster root
Gentiana macrophylla
shepherd's purse
Yerba mate
fungal enzymes blend (proprietary)
peach
noni
Wood betony
biota seed
White oak
Abies spectabilis
Sichuan pepper
soursop
geranium
arnica
star of Bethlehem
clematis
sea salt
3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Alcohol
Aralia
arjuna
Akebia
antler
Agastache
Alseodaphne andersonii
angel\'s trumpet
Aquilegia viridiflora
alpha-humulene
alpha-terpineol
Agrimony
Antrodia camphorata
Achyranthes
Auricularia
Abrus
Alchornea
American Pawpaw
Amomum
Asarum heterotropoides
Albizia
Alchemilla
Aconite
asafoetida
Ajuga
aucubin
andrographolide
Anserina
Agmatine
Aerva lanata
Agarwood
American Liverleaf
Anemone
Aquilegia formosa
Asam gelugor
Angostura
Andrographis
Alstonia scholaris
Actaea spicata
Agonandra
Agrimonia pilosa
Acer truncatum
arjunic acid
Allyl isothiocyanate
aspen
Ashoka
argan nut oil
asarabacca
Abuta
Alstonia macrophylla
Amor seco
Arani
Arisaema
atractylone
betony
Baikal Skullcap
blue flag
Bryonia
Baliospermum
Black spruce
blackthorn
bleeding heart
Bulnesia sarmientoi
bergenin
blubber oil
breadnut
Blepharis
Boswellic Acid
bistort
Baccharis dracunculifolia
Barleria
Berberis (unspecified)
Bougainvillea
Brazilian peppertree
bugbane
bisabolene
benfotiamine
bael
butternut
bindweed
bogbean
black gram
Bauhinia
Boswellia
bethroot
banyan
Black willow
ba ji tian
barbasco
barbary matrimony vine
Borassus aethiopum
borage
black root
baobab
Bupleurum
bittersweet
Bassia scoparia
burning bush
Black Hellebore
bee venom
Bergenia
bottle gourd
cumin
Centella triterpenes
Calendula
Casearia esculenta
Monkey flower
Chinese mountain ant
California redbud
Calotropis gigantea
carrapicho
Cucurbita
Codonopsis
Cnidium
Clerodendrum phlomidis
cactus
Cynomorium
cinquefoil
Cyathula
citron
cashew
Chinese fleeceflower
Cymbidium goeringii
cannabinol
cramp bark
Chinese pond turtle
cajuput
chuchuhuasi
Cymbopogon martini
Centella asiatica
coca
capers
celandine
cinnamic acid
Ceylon leadwort
Cetylated Fatty Acids
Cissus sicyoides
Chinese Ligustrum berry
Campylandra fimbriata
Chenopodium
Chilean wildnut
Cistus
corktree
cubeb
cypress
cowslip
cranesbill
Crinum latifolium
Chaenomeles lagenaria
cannabidiol
Carlina
calamus
cherimoya
Cyanthillium cinereum
Corydalis
Cynodon dactylon
Chiococca alba
Collinsonia
Celastrus
copaiba oil
colocynth
cola nut
Cynanchum
California False Hellebore
cupuacu
Casearia sylvestris
culvers Root
currant
Calycophyllum
Cannabidiolic acid
Dimorphandra mollis
D-phenylalanine
Didymocarpus
dendrobine
divi-divi
Dicentra formosa
danshen
dense fruit dittany
deer root
dodeca-2E, 4E-dienoic acid isobutylamide
dill
dianthrone
dwarf morning glory
Dolichos
Dimethyl sulfoxide (DMSO)
Dimorphandra gardneriana
Dipsacus
dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide
European Elder
Erythropalum scandens
Erigeron
Evodia
English horsemint
Euryale seed
Erythrina
elk antler
emblicanin
emu oil
Echinodorus
enzyme blend
Eupatorium
elemi
Embelia
eugenol
fig
fiesta flower
fritillary
fang-feng
Ficus religiosa
Fomitopsis pinicola
fernbush
Fagopyrum
fringetree
frankincense
fireweed
finger-leaf morning glory
goldthread
Gelsemium
geraniol
Gentianella alborosea
golden eye-grass
Graviola
giant trillium
grains of paradise
garden cress
Gardenia jasminoides
golden ragwort
Galbanum
golden shower tree
Golden Willow
Guazuma ulmifolia
horse gram
Heartsease
Hyperoside
hartstongue
Hemidesmus
Homalomena
Hellebore
Hypericum
honey loquat syrup
huckleberry
Hempnettle
Harpagoside
Indian pipe
Indian nightshade
iridoid glycosides
Iporuru
isobutylamides
Japanese kadsura
Japanese waxtree
joe-pye
judastree
Jatoba
Javanese Long Pepper
Kigelia africana
Khella
Kalanchoe pinnatum
knotgrass
loquat
Lactucarium
Lady of the Night
Ledebouriella
Lesser speargrass
Lilium polyphyllum
linden
Lophira lanceolata
Lactucopicrin
limonene
Lindera
Lavandin
Lespedeza capitata
lotus
Leptadenia
Large-leaved linden
lily
lupulinum
Liquidambar taiwaniana
Loranthus
Lysimachia
Labdanum
Mentha haplocalyx
Mesua
Mezoneuron benthamianum
Myrcene
Marjoram
Marsh Tea
mace
Malay bush
Matico
Mountain mahogany
madder
Matapalo Tree
Mistletoe
mangostin
Maytenus krukovii
Mountain pride
Mimosa
Meadow sage
Microtea debilis
Mate
Meadowsweet
mandrake
Maclura tricuspidata
Millettia
Manchurian thorn
manzanita
Maytenus ilicifolia
New Jersey Tea
Nardostachys
Nordihydrocapsaicin
Night jessamine
Oak
Ocotillo
orchid
Otoba
Oldenlandia diffusa
Operculina turpethum
Osmanthus
Oxindole alkaloids
Paullinia tomentosa
Piperine
Premna
Palmyra
Phragmites
Piper chaba
Psacalium peltatum
pussywillow
Pulsatilla
Patchouli oil
Pterospermum
Pepper Bark Tree
Plumeria lancifolia
pogoda tree
Petasines
proteolytic enzymes
Polypodium
Phlomis umbrosa
Pellitory
Phthalides
Piper retrofractum
Pentatropis capensis
Pareira
Plumbago zeylanica
Pimpinella
Persimmon
paeoniflorin
Pasuchaca
poppy
Pea
Pycnogenol
Palo Azul
Plectranthus amboinicus
Plukenetia volubilis
Potentilla
Prosopis
Palmitoylethanolamide (PEA)
Qin Jiao
Rubus
Rubiaceae
rose
Rooibos
Rhus coriaria
Rosa laevigata
Rosa roxburghii
Rhododendron
Sanicle
Spilanthes
Sinapis arvensis
Silkmoth
Stephania root
Speedwell
Scoparia dulcis
Soft rush
Sumbul
Spikenard
Salicin
Snakeroot
Sanguisorba
Scimitar bean
Southernwood
Spiraea
Salmon Oil
Safed musli
Solanum anguivi
Slippery Elm
Sarcandra glabra
Savory
Sida cordifolia
Spatholobus
Semecarpus anacardium
Skunkvine
Stachytarpheta cayennensis
Scopoletin
Shataverins
Sweet Bay
Storax
Sweet Clover
Sandy Everlasting
Stone Root
Sargassum
Sassafras
Sweet Orange alcohol
Teucrium marum
Tree of heaven
Taxillus sutchuenensis
Tonka Bean
Traveler's Joy
Taxillus chinensis
Takuna
Turtle Head
Tasmannia lanceolata
Toadflax
Taraxacum
Trailing Arbutus
Tetrahydropalmatine
Vetiver
Vervain
Viburnum
Verbena
Veronica
Vanilla
Willow
Weak Jumby Pepper
Walnut
Willow Bracket
Yuzu
Yerba Mansa
Yellow-Fruit Nightshade
Yellow Nut Sedge
Yellow Dock
Zapilopatle Bean
Zingibain

Other health conditions supported by magnesium

Abdominal Pain
Abscesses
Acid Indigestion
Addictions (drugs)
Addictions (general remedies for)
Adrenal Fatigue
Aging (prevention)
Alcoholism
Alkalosis
Allergies (respiratory)
Alzheimer's Disease
Angina
Anorexia
Anxiety
Anxiety Disorders
Apathy
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Athletic and Exercise Aids
Attention Deficit Disorder
Autism
Autoimmune Disorders
Backache
Bipolar Mood Disorder
Birth Control (countering side effects)
Body Building
Body Odor
Boils
Broken Bones
Bronchitis
Bulimia
Calcium Deficiency
Calcium Deposits
Cancer Treatment (reducing side effects)
Canker Sores
Carbuncles
Cardiac Arrest
Cardiovascular Disease
Chest Pain
Cholesterol (high)
Circulation (poor)
Colon (atonic)
Constipation (adults)
Convulsions
Cramps (leg)
Cramps (menstrual)
Cramps and Spasms
Depression
Diabetes
Digestion (poor)
Dizziness
Dysmenorrhea
Emotional Sensitivity
Endurance (lack of)
Energy (lack of)
Epilepsy
Exercise
Fatigue
Fibromyalgia Syndrome
Gastritis
Headache (cluster)
Headache (general)
Headache (tension)
Hearing Loss
Heart (weakness)
Heart Fibrillation or Palpitations
Hypertension
Insomnia
Mental Illness
Migraine
Mood Swings
Muscle Tone (lack of)
Nerve Damage
Nervous Exhaustion
Nervousness
Neurosis
Numbness
Osteoporosis
Oxygen Deficiency
Pain (general remedies for)
Paralysis
Pets (supplements for)
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
Post Partum Depression
Post Partum Weakness
Post Traumatic Stress Disorder
Pregnancy (herbs and supplements for)
Progesterone (low)
Psoriasis
Restless Leg Syndrome
Rhinitis
Seasonal Affective Disorder
Seizures
Senility
Shock
Skin (dry and/or flaky)
Skin Care (general)
Sleep (restless and disturbed)
Stress
Sugar Cravings
Surgery (healing from)
Surgery (preparation for)
Tachycardia
Tension
Testosterone (low)
Tetanus
Thinking (cloudy)
Tics
Tinnitus
TMJ
Tooth Decay
Toxemia
Triglycerides (high)
Twitching
Wasting
Wheezing
Worry
Wounds and Sores