Evidence supporting the use of: Trace minerals
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Trace minerals, including elements such as zinc, selenium, copper, manganese, and iodine, play vital roles in numerous physiological processes, including the healthy functioning of the ovaries. Scientific research confirms that several trace minerals are essential cofactors for enzymes involved in hormone synthesis, follicular development, and ovulation. For example, zinc is required for the synthesis and regulation of reproductive hormones such as estrogen and progesterone, and its deficiency has been linked to menstrual irregularities and impaired fertility. Selenium acts as an antioxidant, protecting ovarian tissue from oxidative stress, while iodine is necessary for thyroid hormone production, which indirectly impacts ovarian function. Copper and manganese also participate in antioxidant defense and enzymatic activities within reproductive tissues.

However, while the essentiality of trace minerals for overall reproductive health is well established, direct evidence specifically linking trace mineral supplementation to enhanced ovarian function in healthy individuals is limited. Most studies focus on populations with deficiencies or specific reproductive disorders such as polycystic ovary syndrome (PCOS) or infertility. In these cases, correcting deficiencies has been associated with improvements in ovarian parameters. Thus, while trace minerals are scientifically validated as necessary for proper ovarian function, the evidence for supplementation beyond correcting deficiencies is moderate, justifying a rating of 3 out of 5.

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