Evidence supporting the use of: DHEA (dehydroepiandrosterone)
For the body system: Ovaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

DHEA (dehydroepiandrosterone) is an endogenous steroid hormone produced primarily by the adrenal glands, and it serves as a precursor to both androgens and estrogens. Its use in supporting the ovarian body system is primarily based on scientific studies, particularly in the context of female fertility and ovarian function. Several clinical trials and meta-analyses have investigated DHEA supplementation in women with diminished ovarian reserve (DOR) or poor ovarian response during in vitro fertilization (IVF) cycles.

The scientific evidence suggests that DHEA supplementation may improve ovarian response, increase the number of retrieved oocytes, and potentially enhance pregnancy rates in women with DOR or poor responders. The proposed mechanisms include upregulation of androgen receptors in ovarian follicles, improved follicular environment, and increased secretion of insulin-like growth factor-1 (IGF-1). However, it is important to note that while some studies and reviews report positive outcomes, others find limited or no significant benefit. As a result, major reproductive medicine societies regard DHEA as experimental, and its use is not universally recommended.

In summary, DHEA is used to support ovarian function based on a moderate body of scientific evidence, mostly in the context of fertility treatments for women with specific ovarian insufficiency issues. The evidence is promising but not definitive, warranting a rating of 3 out of 5.

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