Evidence supporting the use of: Hesperidin
For the health condition: Osteoporosis

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperidin, a flavonoid abundantly found in citrus fruits, has been investigated for its potential benefits in bone health, including the prevention and treatment of osteoporosis. Preclinical studies, primarily in animal models and in vitro experiments, have shown that hesperidin can positively influence bone metabolism. Mechanistically, hesperidin appears to promote osteoblast (bone-forming cell) activity while inhibiting osteoclast (bone-resorbing cell) differentiation, possibly through modulation of oxidative stress and inflammatory pathways. For example, studies in ovariectomized rats (a common model for postmenopausal osteoporosis) demonstrated that hesperidin supplementation improved bone mineral density and bone microarchitecture compared to controls. Additionally, hesperidin’s antioxidant properties may help mitigate oxidative stress, which is implicated in the pathogenesis of osteoporosis. Despite these promising findings, clinical evidence in humans is limited. Few, if any, randomized controlled trials have directly assessed hesperidin's efficacy for osteoporosis in human subjects. Thus, while there is a scientific rationale and some experimental support for hesperidin’s use in osteoporosis, the evidence is not robust enough to warrant strong recommendations, and more high-quality clinical research is needed. Consequently, current support for hesperidin in osteoporosis is based largely on experimental data rather than established clinical practice.

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