Evidence supporting the use of: Magnesium
For the health condition: Mood Swings

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Magnesium is increasingly recognized for its potential role in supporting mood and emotional stability. Scientific research highlights that magnesium is involved in over 300 enzymatic reactions in the body, many of which are critical for nervous system function and neurotransmitter regulation. Several observational studies have found that individuals with low magnesium levels are more likely to experience symptoms of depression, anxiety, and mood swings. Randomized controlled trials have shown that magnesium supplementation may reduce depressive symptoms and improve mood, especially in individuals with existing deficiencies or those under chronic stress. However, the evidence is not universal; some studies report modest or no effects, and more large-scale, high-quality trials are needed. Mechanistically, magnesium helps modulate the activity of the hypothalamic-pituitary-adrenal (HPA) axis, reduce inflammation, and regulate NMDA receptors, all of which are implicated in mood regulation. While magnesium is not a replacement for established psychiatric treatments, it is considered a supportive measure, particularly in people who are deficient. Clinical guidelines sometimes recommend magnesium as an adjunct in mood disorder management, though it is not a first-line therapy. In summary, while the scientific evidence supporting magnesium’s role in treating mood swings is moderate and still emerging, its biological plausibility and favorable safety profile make it a reasonable adjunctive option, especially in cases of known deficiency.

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More about Mood Swings

Other health conditions supported by magnesium

Abdominal Pain
Abscesses
Acid Indigestion
Addictions (drugs)
Addictions (general remedies for)
Adrenal Fatigue
Aging (prevention)
Alcoholism
Alkalosis
Allergies (respiratory)
Alzheimer's Disease
Angina
Anorexia
Anxiety
Anxiety Disorders
Apathy
Arrhythmia
Arteriosclerosis
Arthritis
Asthma
Athletic and Exercise Aids
Attention Deficit Disorder
Autism
Autoimmune Disorders
Backache
Bipolar Mood Disorder
Birth Control (countering side effects)
Body Building
Body Odor
Boils
Broken Bones
Bronchitis
Bulimia
Calcium Deficiency
Calcium Deposits
Cancer Treatment (reducing side effects)
Canker Sores
Carbuncles
Cardiac Arrest
Cardiovascular Disease
Chest Pain
Cholesterol (high)
Circulation (poor)
Colon (atonic)
Constipation (adults)
Convulsions
Cramps (leg)
Cramps (menstrual)
Cramps and Spasms
Depression
Diabetes
Digestion (poor)
Dizziness
Dysmenorrhea
Emotional Sensitivity
Endurance (lack of)
Energy (lack of)
Epilepsy
Exercise
Fatigue
Fibromyalgia Syndrome
Gastritis
Headache (cluster)
Headache (general)
Headache (tension)
Hearing Loss
Heart (weakness)
Heart Fibrillation or Palpitations
Hypertension
Insomnia
Mental Illness
Migraine
Mood Swings
Muscle Tone (lack of)
Nerve Damage
Nervous Exhaustion
Nervousness
Neurosis
Numbness
Osteoporosis
Oxygen Deficiency
Pain (general remedies for)
Paralysis
Pets (supplements for)
PMS (general)
PMS Type A
PMS Type C
PMS Type D
PMS Type H
PMS Type P
Post Partum Depression
Post Partum Weakness
Post Traumatic Stress Disorder
Pregnancy (herbs and supplements for)
Progesterone (low)
Psoriasis
Restless Leg Syndrome
Rhinitis
Seasonal Affective Disorder
Seizures
Senility
Shock
Skin (dry and/or flaky)
Skin Care (general)
Sleep (restless and disturbed)
Stress
Sugar Cravings
Surgery (healing from)
Surgery (preparation for)
Tachycardia
Tension
Testosterone (low)
Tetanus
Thinking (cloudy)
Tics
Tinnitus
TMJ
Tooth Decay
Toxemia
Triglycerides (high)
Twitching
Wasting
Wheezing
Worry
Wounds and Sores