Evidence supporting the use of: Magnesium
For the body system: Mitochondria

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Magnesium is justified for mitochondrial support by scientific evidence. Magnesium is an essential mineral that acts as a cofactor for more than 300 enzymatic reactions in the body, many of which are directly involved in energy metabolism. It plays a critical role in the function of mitochondria, the “powerhouses” of the cell, which are responsible for producing adenosine triphosphate (ATP) via oxidative phosphorylation. Magnesium is required for the stability and activity of ATP; ATP exists primarily as a magnesium-ATP complex in cells. Research has demonstrated that magnesium deficiency impairs mitochondrial function, leading to decreased ATP production and increased oxidative stress (Barbagallo & Dominguez, 2017). Additionally, studies in both animal models and humans have shown that magnesium supplementation can help restore mitochondrial efficiency, protect against mitochondrial dysfunction, and improve cellular resilience in the context of metabolic and neurodegenerative disorders (Nielsen, 2018). While more clinical trials are needed to determine the therapeutic benefits in specific diseases, the fundamental biochemical role of magnesium in mitochondrial energy production is well established. Thus, the use of magnesium to support mitochondrial function is supported by scientific evidence, though not all claims (such as for boosting energy in healthy individuals) are equally well proven.

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cardarine
cardiolipin
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chocolate
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fucoxanthin
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