Evidence supporting the use of: Bupleurum falcatum
For the health condition: Migraine

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Synopsis

Source of validity: Traditional
Rating (out of 5): 1

Bupleurum falcatum, commonly known as Chinese Thoroughwax, is a traditional medicinal herb widely used in Chinese and East Asian medicine. Its primary applications have historically focused on "harmonizing" the liver and alleviating fever, pain, and inflammation. In the context of migraine, bupleurum is not a primary or well-documented traditional remedy, but it is sometimes included in multi-herb formulations such as Chai Hu Shu Gan San, which are used in Traditional Chinese Medicine (TCM) to address headaches, including migraines, believed to be caused by "liver qi stagnation" or stress. The rationale is based on TCM theory, not on direct evidence of efficacy against migraines.

Scientific research directly linking bupleurum falcatum to migraine relief is limited and inconclusive. A few preclinical studies suggest anti-inflammatory and neuroprotective effects of its active compounds, such as saikosaponins, but no high-quality clinical trials have established its effectiveness specifically for migraine. Therefore, the use of bupleurum for migraines is primarily justified by traditional use and theoretical mechanisms in TCM, rather than robust scientific validation.

In summary, while bupleurum is sometimes used in traditional medicine formulas aimed at headaches or migraines, there is very limited scientific evidence to support its efficacy for this specific condition, and its use remains largely based on tradition.

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Other ingredients used for Migraine

5-Hydroxytryptophan (5-HTP)
alpha-linolenic acid (ALA)
ashwagandha
bergamot
beta caryophyllene
black tea
Indian frankincense
bupleurum falcatum
Chinese salvia root
coenzyme Q10 (CoQ10)
turmeric
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
feverfew
fish oil
ginger
ginkgo biloba
gooseberry
gotu kola
kudzu
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
lavender
luteolin
magnesium
Melatonin
Moringa
Niacin (vitamin B3)
omega-3 fatty acids
Peppermint
phytocannabinoids
pine bark
purple butterbur root
riboflavin (vitamin B2)
specialized pro-resolving mediators (SPMs)
Almond fruit
ubiquinol
Valerian root
vitamin B6
vitamin D
vitamin D3
vitamin E
Zinc
atractylodes
blackboard tree
Swertia
Szechuan lovage
chrysanthemum
soursop
1,3,7-Trimethylpurine-2,6-dione
5-methyltetrahydrofolate glucosamine
apple cider vinegar
Albizia
alpha-lipoic acid
atractylone
betony
black seed
Baikal Skullcap
beta-hydroxybutyrate
Blepharis
balsam
banyan
brahmi
butterbur
Bifidobacteria
Black Hellebore
Chinese silkvine
crocin
creatine
cannabidiol
Corydalis
Carthamus
cola nut
docosahexaenoic Acid
danshen
eicosapentaenoic acid
folic acid
flavin mononucleotide
Ficus religiosa
fish
flavanones
Ficus simplicissima
frankincense
goldthread
Gelsemium
ginkgolides
Ginkgoside
Hellebore
iridoids
ketone salts
kuding tea
lemon balm
Lesser speargrass
little ironweed
linalool
Mesua
Methylxanthine
Meadowsweet
Nardostachys
Night jessamine
Osthole
Puerarin
Petasines
Phthalides
paeoniflorin
Pycnogenol
Polygonum
Palmitoylethanolamide (PEA)
rue
Rubus
Rauvolfia
Rubiaceae
Spikenard
Sensitive Plant
Salmon Oil
Sandalwood
Scabrous Gentian
Uncaria
Withanolides
Xanthine
Xanthophyll
Xanthone
Yuzu
Zingerone