Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin C (ascorbic acid) is sometimes considered for the management of Metabolic Syndrome (MetS) due to its antioxidant properties and potential role in reducing oxidative stress, which is elevated in individuals with MetS. Several observational studies have found that people with MetS often have lower plasma vitamin C concentrations. Some interventional studies suggest that vitamin C supplementation may modestly improve certain components of MetS, such as blood pressure, fasting blood glucose, and lipid profiles. For instance, a 2017 meta-analysis found that vitamin C supplementation produced small but statistically significant reductions in systolic and diastolic blood pressure. Other clinical trials have reported reductions in markers of oxidative stress and inflammation, which are critical in MetS pathogenesis. However, the overall quality of evidence is moderate to low. Large, well-conducted randomized controlled trials specifically targeting MetS populations are limited, and the observed effects are generally mild. Most guidelines do not recommend vitamin C as a primary therapy for MetS, but it may have an adjunctive role, especially in those with poor dietary intake. In summary, while there is some scientific rationale and preliminary evidence supporting vitamin C’s use in MetS, it is not strongly validated, and its effects are likely modest compared to established therapies such as lifestyle modification and pharmacotherapy.

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Products containing vitamin C

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