Evidence supporting the use of: DHEA (dehydroepiandrosterone)
For the health condition: Menopause

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHEA (dehydroepiandrosterone) is an endogenous steroid hormone produced by the adrenal glands, serving as a precursor to both androgens and estrogens. Its use to support menopause is primarily based on scientific investigation, although the overall quality and consistency of evidence are modest. During menopause, endogenous DHEA levels decline, which has led to the hypothesis that supplementation might alleviate menopausal symptoms such as hot flashes, decreased libido, and mood changes. Several randomized controlled trials have explored DHEA supplementation for menopausal women, with mixed results. Some studies report modest improvements in sexual function, bone mineral density, and vaginal atrophy, while others find no significant benefit over placebo. Systematic reviews and meta-analyses generally conclude that DHEA may offer limited benefit for vulvovaginal symptoms and sexual dysfunction, but does not consistently improve global menopausal symptoms.

DHEA is not considered a first-line treatment for menopause according to major clinical guidelines, and concerns about potential androgenic side effects and long-term safety persist. However, it is sometimes used in clinical practice for women who do not tolerate conventional hormone therapy. Overall, the evidence supporting DHEA's use in menopause is weak to moderate, justifying a rating of 2 out of 5.

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