Centipeda, particularly Centipeda minima (also known as "E Bu Shi Cao" in Traditional Chinese Medicine), has a long history of traditional use in East Asian herbal medicine, especially for respiratory system ailments. In classical Chinese medicine, it is employed to "dispel phlegm," "relieve cough," and "open the nasal passages," suggesting its primary association with supporting the Lung system. Traditional practitioners have used Centipeda preparations for symptoms such as chronic rhinitis, sinusitis, and cough. The herb is believed to have anti-inflammatory and anti-allergic properties according to traditional theory.

Scientific validation for Centipeda’s effects on the lungs is limited. Some in vitro and animal studies indicate that extracts of Centipeda minima may have anti-inflammatory and anti-allergic activities, and may inhibit histamine release—mechanisms potentially relevant to respiratory conditions. However, there are few well-designed human clinical trials confirming efficacy or safety in supporting lung health. As a result, while its use is deeply rooted in tradition, the evidence base is not robust by modern scientific standards and merits a moderate evidence rating.