Evidence supporting the use of: Psyllium
For the health condition: Leaky Gut Syndrome

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Psyllium, a soluble fiber derived from the husks of Plantago ovata seeds, is sometimes recommended as part of protocols to support “Leaky Gut Syndrome”—a controversial condition characterized by increased intestinal permeability. While the clinical diagnosis of "leaky gut" is not widely recognized in conventional medicine, the concept of intestinal barrier dysfunction is a legitimate area of scientific investigation.

Psyllium’s proposed benefit comes from its prebiotic effect: it resists digestion in the upper GI tract and is fermented by gut microbiota in the colon. This fermentation produces short-chain fatty acids (SCFAs), such as butyrate, which support intestinal epithelial health and may enhance the integrity of tight junctions between gut cells. Animal studies and in vitro research have shown psyllium can increase mucus secretion and promote the growth of beneficial bacteria, both of which may help maintain or restore barrier function.

However, direct scientific evidence in humans specifically linking psyllium supplementation to improvements in “leaky gut” or measurable decreases in intestinal permeability is limited. Most studies focus on irritable bowel syndrome (IBS), constipation, and general bowel health. Some small trials suggest that dietary fibers like psyllium can reduce markers of inflammation and improve gut barrier function, but results are preliminary.

In summary, while there is a plausible scientific rationale and some mechanistic evidence, robust clinical trials in humans are lacking. The evidence supporting psyllium for “leaky gut” is thus limited but emerging.

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