Evidence supporting the use of: Folate
For the health condition: Infertility

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Folate (vitamin B9) has a scientifically validated role in supporting fertility, especially in women. Multiple studies have shown that adequate folate intake is associated with improved reproductive outcomes. Folate is crucial for DNA synthesis, repair, and methylation, all vital processes in oocyte (egg) maturation and early embryonic development. Folate deficiency is linked to neural tube defects in offspring, but it also appears to impact fertility by increasing the risk of ovulatory infertility.

A number of observational studies have demonstrated that women taking folic acid supplements (the synthetic form of folate) have higher pregnancy rates when trying to conceive, both naturally and through assisted reproductive technologies like IVF. One notable study published in Fertility and Sterility (2012) found that higher folate intake was associated with higher rates of live birth after IVF. Another large study from the American Journal of Clinical Nutrition (2016) observed that women with higher folic acid intake had a lower risk of infertility due to ovulation disorders.

Men may also benefit: research suggests folate may improve sperm quality, although the evidence is less robust than in women. Professional guidelines, including those from the American College of Obstetricians and Gynecologists (ACOG), recommend folic acid supplementation for women of childbearing age, mainly to prevent birth defects, but the fertility benefits provide further support for its use during preconception.

Overall, the use of folate to support fertility is backed by scientific evidence, reflected in its widespread recommendation in reproductive medicine.

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