Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonones, a subclass of flavonoids commonly found in citrus fruits (such as hesperidin and naringenin), have been investigated for their potential immune-supporting properties. Scientific studies, primarily in vitro and in animal models, suggest that flavonones can modulate immune system activity through their antioxidant and anti-inflammatory effects. They appear to influence cytokine production, support the function of certain immune cells (like macrophages and lymphocytes), and may help protect against oxidative stress that can impair immune responses.

Some limited human studies indicate that consumption of flavonone-rich foods or extracts can reduce markers of inflammation and oxidative stress, which are linked to the body’s immune defense mechanisms. For example, hesperidin has been shown in small clinical studies to reduce inflammation and improve endothelial function, indirectly supporting immune health. However, robust clinical trials specifically demonstrating that flavonones directly enhance immune system function in humans are lacking, and most evidence is extrapolated from preclinical research.

Overall, while there is a scientific basis for the use of flavonones to support aspects of immune health, particularly due to their antioxidant and anti-inflammatory properties, the direct evidence in humans is moderate and not definitive. Thus, the evidence rating is 3 out of 5, acknowledging promising but not conclusive support.

More about Flavonones (unspecified)
More about Immune System

Other ingredients that support Immune System

Other body systems supported by Flavonones (unspecified)

Products containing Flavonones (unspecified)