Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Relora® is a proprietary blend typically composed of extracts from Magnolia officinalis and Phellodendron amurense. Its use for supporting the hypothalamus body system—specifically in relation to stress and cortisol regulation—has some scientific basis, though evidence is limited and primarily consists of small clinical studies and preclinical data. The hypothalamus is a brain region crucial for regulating the body's stress response via the hypothalamic-pituitary-adrenal (HPA) axis. Relora® has been studied for its potential to reduce perceived stress and cortisol levels, presumably by modulating this axis.

Several randomized, placebo-controlled trials have reported that Relora® supplementation may reduce self-reported feelings of stress and anxiety, and lower salivary cortisol levels in subjects experiencing stress. For example, a 2006 study (Talbott et al., J Int Soc Sports Nutr) found that individuals taking Relora® showed reduced cortisol exposure and improved mood compared to placebo. However, these studies often have small sample sizes, short durations, and some methodological limitations.

There are no large-scale, long-term clinical trials specifically focused on hypothalamic function or direct measures of HPA axis activity in relation to Relora®. Thus, while there is some scientific evidence that Relora® may indirectly support the hypothalamus by influencing stress and cortisol, the overall evidence base is modest and further research is warranted.

More about relora® (proprietary)
More about Hypothalamus

Other ingredients that support Hypothalamus

Other body systems supported by relora® (proprietary)

Products containing relora® (proprietary)

Nature's Sunshine Cortisol Formula (Nature's Cortisol Formula)