Evidence supporting the use of: Glycyrrhizinic acid
For the health condition: Herpes

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Synopsis of Glycyrrhizinic Acid for Herpes

Glycyrrhizinic acid, a major constituent of licorice root (Glycyrrhiza glabra), has been studied for its antiviral properties, including activity against herpes simplex virus (HSV). Several in vitro studies have demonstrated that glycyrrhizinic acid can inhibit the growth of HSV-1 and HSV-2 by interfering with viral replication and suppressing virus-induced cytopathic effects. For example, a study published in Antiviral Research (Pompei et al., 1979) found that glycyrrhizinic acid inhibited HSV replication in cell cultures. Additionally, more recent research has suggested possible mechanisms, including interference with viral gene expression and modulation of immune responses.

Despite promising laboratory results, clinical evidence in humans is limited. There are very few, if any, high-quality randomized controlled trials examining the effectiveness of glycyrrhizinic acid for treating herpes infections in people. Most supportive evidence comes from preclinical studies, and only anecdotal or traditional use points to its application in human herpes infections. Safety concerns, such as the risk of pseudoaldosteronism and hypertension with prolonged licorice use, also limit its therapeutic potential.

In summary, while there is scientific rationale and preclinical evidence suggesting antiviral activity against herpes viruses, the overall level of clinical evidence is low, justifying a modest rating of 2 out of 5.

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