Polygonatum cirrhifolium, commonly known as "Whorled Solomon's Seal," has a longstanding history of use in traditional medicine systems, particularly in the Himalayas and parts of China and India. Ethnobotanical surveys and traditional medical texts note its application for a variety of ailments, including headache, although it is not one of its most prominent uses. Local healers and traditional practitioners have employed the rhizome or root extracts to relieve general pain and inflammation, which could encompass headaches. However, the specific documentation for its exclusive or primary use in treating headaches is sparse, and references are often anecdotal or generalized under pain-relieving or anti-inflammatory effects in folk medicine.

There is currently no robust scientific evidence or clinical trials supporting the efficacy of Polygonatum cirrhifolium for headache management. Most available documentation centers around its traditional use, with only limited phytochemical studies suggesting antioxidant and anti-inflammatory properties in vitro, which may theoretically contribute to pain relief. Therefore, while its use for headache is justified by tradition and some community practices, the overall strength of evidence remains low, largely due to the absence of detailed pharmacological studies or clinical validation.