Hesperidin is a flavonoid predominantly found in citrus fruits. Its use in supporting gum (periodontal) health has some basis in scientific research, though the evidence is limited and not robust. Hesperidin exhibits anti-inflammatory and antioxidant properties, which are theoretically beneficial for oral health, especially in reducing gum inflammation and oxidative stress associated with periodontal disease. Some laboratory and animal studies suggest that hesperidin can inhibit the formation of pro-inflammatory cytokines and reduce tissue damage in models of periodontitis. For example, hesperidin has shown the ability to decrease markers of inflammation and support tissue healing in experimental periodontitis in rats. Additionally, its antioxidant effects may help counteract oxidative stress in gum tissues, which is a contributing factor in gum disease.

However, clinical evidence in humans is sparse. While hesperidin is included in some oral health products and supplements aimed at supporting gum health, few high-quality human trials have directly assessed its effectiveness for this purpose. Most available data are extrapolated from studies on its general anti-inflammatory and vascular benefits, or from research on related flavonoids. Therefore, while there is some scientific rationale and preliminary evidence for hesperidin's role in supporting gum health, especially for its anti-inflammatory effects, the quality and quantity of direct human evidence remain modest, justifying a low to moderate evidence rating.