Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Serratiopeptidase is a proteolytic enzyme originally isolated from bacteria found in the intestines of silkworms. It is primarily marketed and prescribed in certain countries (notably India and Japan) for its anti-inflammatory and anti-edemic properties. The rationale for its use in cases of "swollen lymph glands" (lymphadenopathy), often due to infections or inflammatory processes, is based on its purported ability to reduce inflammation and tissue swelling (edema). Several small studies and animal models suggest that serratiopeptidase can decrease inflammatory mediators, promote the breakdown of fibrin and protein-based debris, and improve microcirculation, potentially reducing swelling. However, direct scientific evidence specifically supporting serratiopeptidase for the treatment of swollen lymph glands is limited and of low quality. Most clinical studies focus on its use in postoperative swelling, sinusitis, or other inflammatory conditions, rather than lymphadenopathy itself. Systematic reviews highlight a lack of large, high-quality randomized controlled trials. While some clinicians may use it off-label for swollen glands based on its general anti-inflammatory effects, the evidence remains preliminary and inconclusive. Regulatory bodies in many Western countries do not approve or recommend serratiopeptidase for this indication. In summary, while there is a scientific rationale and some preliminary evidence for its anti-inflammatory effects, robust clinical validation specifically for swollen lymph glands is lacking, resulting in a low overall evidence rating.

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