Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Prickly Ash Bark (Zanthoxylum americanum or Zanthoxylum clava-herculis) has a long history of use in traditional herbal medicine, especially in North American and some Chinese herbal systems. Herbalists have traditionally recommended prickly ash bark to support the lymphatic system and address swollen glands (enlarged lymph nodes), often in the context of general detoxification, improving circulation, or alleviating symptoms of infections and inflammatory conditions. These uses are largely based on empirical knowledge, folk traditions, and the writings of 19th-century eclectic physicians, who described it as a "stimulant" and "alterative" for sluggish lymphatic flow and glandular swellings.

However, scientific evidence supporting these specific uses is lacking. While prickly ash bark contains bioactive compounds such as alkaloids and coumarins, there are no published clinical studies or robust pharmacological data directly demonstrating its efficacy for treating swollen lymph glands. Most references to this effect are anecdotal or found in historical herbal texts. The evidence rating is therefore low (2/5), reflecting extensive traditional use but insufficient scientific validation. Individuals considering prickly ash bark for swollen glands should consult healthcare professionals and not rely on it as a sole treatment, especially since swollen glands can indicate serious underlying health conditions.

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