Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Hedyotis diffusa (also known as Oldenlandia diffusa or Bai Hua She She Cao) is traditionally used in Chinese herbal medicine, often as part of multi-herb formulas, to address conditions described as "swelling of glands," "toxic heat," or "phlegm-fire," which may correspond to swollen lymph nodes in modern terms. Its use is documented in classical texts and remains common in contemporary Traditional Chinese Medicine (TCM) practice, particularly for infections, abscesses, and as an adjunct in cancer formulas. The underlying theory is that the herb "clears heat and removes toxins," helping to resolve swellings and nodules.

Scientific studies have investigated Hedyotis diffusa for its anti-inflammatory, immunomodulatory, and anticancer properties, but direct clinical evidence for its effectiveness in treating swollen lymph nodes (lymphadenopathy) in humans is limited. Most research consists of in vitro or animal studies, or clinical trials where it is used as part of larger herbal combinations, often for cancer support rather than benign lymph node swelling. Thus, while there is some pharmacological rationale, the primary justification for its use in swollen glands comes from traditional practice rather than robust clinical evidence.

In summary, Hedyotis diffusa's use for swollen glands is primarily traditional, with some preliminary scientific support for related actions, but little high-quality clinical validation specifically for lymphadenopathy.

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